Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

被引：24
|
作者：
D'Este, L
Scontrini, A
Casini, A
Pontieri, FE
Renda, TG
机构：
[1] Fac Med 1, Inst Human Anat, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Fac Med 2, Dept Neurosci, I-00161 Rome, Italy
来源：
BRAIN RESEARCH | 2002年 / 933卷 / 02期
关键词：
c-Fos oncoprotein; heroin; sensitization; caudate-putamen; nucleus accumbens shell; immunohistochemistry;
D O I：
10.1016/S0006-8993(02)02312-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell. whereas the sa-me dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：144 / 149
页数：6
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