DMAP-Catalyzed C-N Bond Formation for Diverse Synthesis of Imidazo[1,2-a]pyrimidine and Pyrimido[1,2-a]benzimidazole Derivatives

被引：10

作者：

Shang, Le-Le ^{[1
]}

Feng, Yun ^{[1
]}

Gao, Xing-Lian ^{[1
]}

Chen, Zi-Ren ^{[1
]}

Xia, Yu ^{[1
]}

Jin, Wei-Wei ^{[1
]}

Liu, Chen-Jiang ^{[1
]}

机构：

[1] Xinjiang Univ, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uygur Autonomous Reg, Urumqi Key Lab Green Catalysis & Synth Technol,Sc, Urumqi 830046, Xinjiang, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2020年 / 38卷 / 12期

基金：

中国国家自然科学基金;

关键词：

2-Dimethylaminopyridine; Aldehydes; Nitrogen heterocycles; Pyrimido[1,2-a]benzimidazoles; Imidazo[1,2-a]pyrimidines; ONE-POT SYNTHESIS; METAL-FREE; REGIOSELECTIVE SYNTHESIS; ANTIMICROBIAL ACTIVITY; STEP SYNTHESIS; ALPHA; ENTRY; PYRIMIDINE; ALDEHYDES; EFFICIENT;

D O I：

10.1002/cjoc.202000214

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Summary of main observation and conclusion A DMAP (2-dimethylaminopyridine)-catalyzed condensation reactions for the successful direct construction of pyrimido[1,2-a]benzimidazole or imidazo[1,2-a]pyrimidine has been developed. The method utilizes readily available alpha-bromocinnamaldehydes with 2-aminobenzimidazole or 2-aminoimidazole as starting materials in the presence of 2-DMAP/TBHP. In the process, two C-N bonds were successfully constructed to synthesize target compounds. The current method features wide substrate scope, product diversification, and metal-free conditions.

引用

页码：1595 / 1599

页数：5

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