The literature concerning the use of anthracyclines in the treatment of non-small cell lung cancer (NSCLC) is reviewed here. Overall. the activity of doxorubicin (DOXO) is unsatisfactory, whereas, the analogous epidoxorubicin (EPI) yields a 30% response rate (RR) when administered at intermediate-high doses. All active drugs, including EPI. should be considered to design the most active combination. Mainly. in the setting. in which an objective response is very important. for instance the neo-adjuvant pre-operatory setting. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
机构:
Yale Univ, Yale Sch Med, Pulm & Crit Care Med Sect, New Haven, CT 06520 USAYale Univ, Yale Sch Med, Pulm & Crit Care Med Sect, New Haven, CT 06520 USA
机构:
Baylor Coll Med, Div Gen Thorac Surg, Michael E DeBakey Dept Gen Surg, Lung Inst, One Baylor Plaza MS390, Houston, TX 77030 USABaylor Coll Med, Div Gen Thorac Surg, Michael E DeBakey Dept Gen Surg, Lung Inst, One Baylor Plaza MS390, Houston, TX 77030 USA
Sugarbaker, David J.
Haywood-Watson, Ricky J.
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机构:
Baylor Coll Med, Michael E DeBakey Dept Gen Surg, One Baylor Plaza MS390, Houston, TX 77030 USABaylor Coll Med, Div Gen Thorac Surg, Michael E DeBakey Dept Gen Surg, Lung Inst, One Baylor Plaza MS390, Houston, TX 77030 USA
Haywood-Watson, Ricky J.
Wald, Ori
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机构:
Baylor Coll Med, Div Gen Thorac Surg, Michael E DeBakey Dept Gen Surg, One Baylor Plaza MS390, Houston, TX 77030 USABaylor Coll Med, Div Gen Thorac Surg, Michael E DeBakey Dept Gen Surg, Lung Inst, One Baylor Plaza MS390, Houston, TX 77030 USA
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
Harvard Med Sch, Boston, MA USA
Dana Farber Canc Inst, 450 Brookline Ave,DA 718, Boston, MA 02215 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
Liu, Shengwu
Lowder, Kristen E.
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机构:
Univ Massachusetts, Sch Med, Chan Med Sch, Worcester, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA USA