Shear activates platelet-derived latent TGF-β

被引：6
|
作者：
Miyazono, Kohei [1 ]
机构：
[1] Univ Tokyo, Tokyo 1138654, Japan
来源：
BLOOD | 2008年 / 112卷 / 09期
关键词：
D O I：
10.1182/blood-2008-07-165696
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although platelets are a rich source of latent TGF-beta it has not been determined how platelet-derived latent TGF-beta is activated in vivo. In this issue of Blood, Ahamed and colleagues report that shear and stirring efficiently activate the latent TGF-beta.
引用
收藏
页码：3533 / 3534
页数：4
相关论文
共 50 条
  • [41] PLATELET-DERIVED VASCULAR MEDIATORS
    SMITH, JB
    THROMBOSIS AND HAEMOSTASIS, 1985, 54 (01) : 320 - 320
  • [42] Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae
    Liu, P.
    Ying, Y.-S.
    Anderson, R. G. W.
    Proceedings of the National Academy of Sciences of the United States of America, 94 (25):
  • [43] Latent TGF-β binding proteins:: Extracellular matrix association and roles in TGF-β activation
    Hyytiäinen, M
    Penttinen, C
    Keski-Oja, J
    CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2004, 41 (03) : 233 - 264
  • [44] Platelet-derived Growth Factor Activates Pericytes in the Microvessels of Chronic Subdural Hematoma Outer Membranes
    Yokota, Mao
    Osuka, Koji
    Ohmichi, Yusuke
    Ohmichi, Mika
    Suzuki, Chiharu
    Aoyama, Masahiro
    Iwami, Kenichiro
    Honma, Satoru
    Miyachi, Shigeru
    NEUROLOGIA MEDICO-CHIRURGICA, 2024, 64 (01) : 50 - 55
  • [45] HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide
    Laurence, Jeffrey
    Elhadad, Sonia
    Robison, Tyler
    Terry, Hunter
    Varshney, Rohan
    Woolington, Sean
    Ghafoory, Shahrouz
    Choi, Mary E.
    Ahamed, Jasimuddin
    PLOS ONE, 2017, 12 (10):
  • [46] Stable CAD patients show higher levels of platelet-borne TGF-β1 associated with a superior pro-inflammatory state than the pro-aggregatory status; Evidence highlighting the importance of platelet-derived TGF-β1 in atherosclerosis
    Javad Ahmadi
    Ehteramolsadat Hosseini
    Faranak Kargar
    Mehran Ghasemzadeh
    Journal of Thrombosis and Thrombolysis, 2023, 55 : 102 - 115
  • [47] TGF-β2 activates proliferative scar fibroblasts
    Smith, P
    Mosiello, G
    Deluca, L
    Ko, F
    Maggi, S
    Robson, MC
    JOURNAL OF SURGICAL RESEARCH, 1999, 82 (02) : 319 - 323
  • [48] Stable CAD patients show higher levels of platelet-borne TGF-β1 associated with a superior pro-inflammatory state than the pro-aggregatory status; Evidence highlighting the importance of platelet-derived TGF-β1 in atherosclerosis
    Ahmadi, Javad
    Hosseini, Ehteramolsadat
    Kargar, Faranak
    Ghasemzadeh, Mehran
    JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2023, 55 (01) : 102 - 115
  • [49] Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator
    Kouzbari, Karim
    Hossan, Mohammad R.
    Arrizabalaga, Julien H.
    Varshney, Rohan
    Simmons, Aaron D.
    Gostynska, Sandra
    Nollert, Matthias U.
    Ahamed, Jasimuddin
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [50] Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator
    Karim Kouzbari
    Mohammad R. Hossan
    Julien H. Arrizabalaga
    Rohan Varshney
    Aaron D. Simmons
    Sandra Gostynska
    Matthias U. Nollert
    Jasimuddin Ahamed
    Scientific Reports, 9
12345