Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

被引：22

作者：

Ortiz-Cuaran, Sandra ^{[1
]}

Villar, Stephanie ^{[1
]}

Gouas, Doriane ^{[1
]}

Ferro, Gilles ^{[1
]}

Plymoth, Amelie ^{[2
]}

Khuhaprema, Thiravud ^{[3
]}

Kalalak, Anant ^{[3
]}

Sangrajrang, Suleeporn ^{[3
]}

Friesen, Marlin D. ^{[4
]}

Groopman, John D. ^{[4
]}

Hainaut, Pierre ^{[1
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon, France

[2] Karolinska Inst, Stockholm, Sweden

[3] Natl Canc Inst, Bangkok, Thailand

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

来源：

CANCER LETTERS | 2013年 / 331卷 / 01期

关键词：

R249S; Hepatitis B virus; Hepatocellularcarcinoma; HBX; HEPATITIS-B-VIRUS; X-PROTEIN; DEVELOPING-COUNTRIES; PATHOGENESIS; EXPOSURE; HEPATOCARCINOGENESIS; PROLIFERATION; INFECTIONS; ETIOLOGY; PLASMA;

D O I：

10.1016/j.canlet.2012.11.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：46 / 51

页数：6

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