Evaluation of Soluble Mesothelin-related Peptide as a Diagnostic Marker of Malignant Pleural Mesothelioma Effusions: Its Contribution to Cytology

被引：21

作者：

Canessa, Pier Aldo ^{[1
]}

Franceschini, Maria Cristiana ^{[2
]}

Ferro, Paola ^{[2
]}

Battolla, Enrico ^{[3
]}

Dessanti, Paolo ^{[2
]}

Manta, Carmen ^{[1
]}

Sivori, Massimiliano ^{[1
]}

Pezzi, Riccardo ^{[4
]}

Fontana, Vincenzo ^{[4
]}

Fedeli, Franco ^{[2
]}

Pistillo, Maria Pia ^{[5
]}

Roncella, Silvio ^{[2
]}

机构：

[1] Div Pneumol, La Spezia, Italy

[2] Div Histopathol & Cytopathol, La Spezia, Italy

[3] Div Clin Pathol ASL5, La Spezia, Italy

[4] IRCCS AOU San Martino IST, Epidemiol Biostat & Clin Trials Unit, Genoa, Italy

[5] IRCCS AOU San Martino IST, Tumor Genet & Epigenet Unit, Genoa, Italy

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 01期

关键词：

Cytology; ELISA; Mesothelin; Mesothelioma; Pleural effusion; Tumor; CLINICAL-SIGNIFICANCE; LUNG-CANCER; BIOMARKERS; EXPERIENCE; MANAGEMENT; PROTEINS; FLUID; SERUM;

D O I：

10.3109/07357907.2012.749265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Soluble mesothelin-related peptide (SMRP) is regarded as an FDA approved biomarker for the diagnosis and monitoring of pleural malignant mesothelioma (MPM). We detected the SMRP levels in pleural effusions (PE) by means of an ELISA and analyzed their diagnostic relevance to differentiate MPM from benign pathology and from non-MPM pleural metastasis. Comparison with cytology in MPM-PE was also performed. We found that SMRP detection in MPM-PE can help the diagnosis of MPM and provide additional diagnostic value to cytology. We concluded that SMRP test may be incorporated into clinical practice of PE from patients suspicious for MPM.

引用

页码：48 / 55

页数：8

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