Evaluating the effectiveness of conjugated pneumococcal vaccines in Colombia

被引：0
|
作者：
Manjarres-Posada, N. I. [1 ]
Choconta-Piraquive, L. A. [1 ]
De la Hoz-Restrepo, F. [1 ]
机构：
[1] Univ Nacl Colombia, Fac Med, Bogota, Colombia
来源：
5TH VACCINE AND ISV ANNUAL GLOBAL CONGRESS | 2012年 / 6卷
关键词：
Streptococcus pneumoniae; Pneumococcal Infections; Pneumococcal Vaccines; Vaccine effectiveness; DISEASE; BURDEN;
D O I：
10.1016/j.provac.2012.04.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A retrospective cohort study was conducted in 2631 Colombian children <2 yrs to evaluate pneumococcal vaccine effectiveness. Association between vaccination and disease was evaluated using Cox proportional hazards models. Vaccinated children had a significant reduction in hospitalization risk for all outcomes (HR 0,59 CI 95% 0,42 0,85) and for pneumonia the reduction was slightly higher (HR 0,53 CI 95% 0,32 - 0,89). Our results show an important risk reduction in clinical syndromes potentially associated to pneumococcus in vaccinated children confirming the benefits of using conjugate vaccines in a medium income developing country. (C) 2012 Published by Elsevier Ltd. Selection and/or peerreview under responsibility of the 5th vaccine confer organizing conunittee.
引用
收藏
页码：150 / 155
页数：6
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