Electrochemical Sensor Based on Fe Doped Hydroxyapatite-Carbon Nanotubes Composite for L-Dopa Detection in the Presence of Uric Acid

被引：12
|
作者：
Kanchana, P. [1 ]
Radhakrishnan, S. [1 ]
Navaneethan, M. [2 ]
Arivanandhan, M. [2 ]
Hayakawa, Y. [2 ]
Sekar, C. [1 ]
机构：
[1] Alagappa Univ, Dept Bioelect & Biosensors, Karaikkudi 630003, Tamil Nadu, India
[2] Shizuoka Univ, Res Inst Elect, Hamamatsu, Shizuoka 4328011, Japan
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2016年 / 16卷 / 06期
关键词：
Fe Doped Hydroxyapatite; CNTs; Composites; Electrochemical Sensor; L-Dopa; MODIFIED ELECTRODE; DRUG; NANOPARTICLES; IMMUNOSENSOR; CARBIDOPA; LEVODOPA; FILM;
D O I：
10.1166/jnn.2016.11645
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel amperometric sensor based on iron doped hydroxyapatite (Fe-HA) and multiwalled carbon nanotubes (CNT) composite immobilized on a glassy carbon electrode (GCE) has been fabricated. The hybrid composite made of Fe-HA nanoparticles and CNT promotes electron transfer kinetics between the analyte levodopa (L-dopa) and the modified GC electrode. Under optimum conditions, the fabricated sensor gave a linear response range of 1.0x10(-7)-1.1x10(-6) M with the detection limit as low as 62 nM. The Fe-HA/CNT modified electrode showed good selectivity towards the determination of L-dopa in the presence of ascorbic acid (AA), uric acid (UA) and other common interferents. The sensor displays a high sensitivity, good reproducibility and long-term stability and it was successfully applied for the detection of L-dopa in pharmaceutical and medicinal plant samples.
引用
收藏
页码：6185 / 6192
页数：8
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