Modular Total Synthesis of Lamellarin G Trimethyl Ether

被引：37

作者：

Yadav, Jhillu S. ^{[1
]}

Gayathri, Kamakolanu Uma ^{[1
]}

Reddy, Basi V. Subba ^{[1
]}

Prasad, Attaluri R. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNLETT | 2009年 / 01期

关键词：

lamellarins; Friedel-Crafts acylation; esterification; bromoarylation; oxidative cyclization; NINGALIN-B; PERMETHYL STORNIAMIDE; ALPHA; 20-SULFATE; ALKALOIDS; LUKIANOL; CONSTRUCTION; DERIVATIVES; INHIBITORS; ASCIDIANS; MOLLUSK;

D O I：

10.1055/s-0028-1087387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modular synthesis of the lamellarin G trimethyl ether has been developed based on the application of several reaction sequences which include Friedel-Crafts acylation, esterification, haloarylation, and oxidative cyclization. The formation of pyrrolo [2,1-a]isoquinoline core, the key step for the successful completion of lamellarin G trimethyl ether synthesis, is comfortably accomplished through the haloarylation of 3-bromo-4-(3,4-dimethoxy-benzoyl)-6,7-dimethoxy-chroman-2-one which has resulted in exclusive endo product.

引用

页码：43 / 46

页数：4

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