Modular Total Synthesis of Lamellarin G Trimethyl Ether

被引：37
|
作者：
Yadav, Jhillu S. [1 ]
Gayathri, Kamakolanu Uma [1 ]
Reddy, Basi V. Subba [1 ]
Prasad, Attaluri R. [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNLETT | 2009年 / 01期
关键词：
lamellarins; Friedel-Crafts acylation; esterification; bromoarylation; oxidative cyclization; NINGALIN-B; PERMETHYL STORNIAMIDE; ALPHA; 20-SULFATE; ALKALOIDS; LUKIANOL; CONSTRUCTION; DERIVATIVES; INHIBITORS; ASCIDIANS; MOLLUSK;
D O I：
10.1055/s-0028-1087387
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular synthesis of the lamellarin G trimethyl ether has been developed based on the application of several reaction sequences which include Friedel-Crafts acylation, esterification, haloarylation, and oxidative cyclization. The formation of pyrrolo [2,1-a]isoquinoline core, the key step for the successful completion of lamellarin G trimethyl ether synthesis, is comfortably accomplished through the haloarylation of 3-bromo-4-(3,4-dimethoxy-benzoyl)-6,7-dimethoxy-chroman-2-one which has resulted in exclusive endo product.
引用
收藏
页码：43 / 46
页数：4
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