Flabelliferins A and B, Sesterterpenoids from the South Pacific Sponge Carteriospongia flabellifera

被引：12
|
作者：
Diyabalanage, Thushara [1 ]
Ratnayake, Ranjala [1 ]
Bokesch, Heidi R. [1 ,2 ]
Ransom, Tanya T. [1 ]
Henrich, Curtis J. [1 ,2 ]
Beutler, John A. [1 ]
McMahon, James B. [1 ]
Gustafson, Kirk R. [1 ]
机构：
[1] Frederick Natl Lab Canc Res, Mol Targets Lab Ctr Canc Res, Frederick, MD 21702 USA
[2] Frederick Natl Lab Canc Res, SAIC Frederick Inc, Basic Sci Program, Frederick, MD 21702 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 08期
基金：
美国国家卫生研究院;
关键词：
MARINE SPONGE; INDONESIAN SPONGE; INHIBITORS; FOLIASCENS;
D O I：
10.1021/np3003518
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sesterterpenoids named flabelliferins A (1) and B (2) were isolated from the lipophilic extract of the sponge Cateriospongia flabellifera, collected in the South Pacific near Vanuatu. The structure and absolute configuration of these two compounds were assigned by a combination of one- and two-dimensional NMR spectroscopy and by Mosher's ester analysis. Flabelliferin A (1) has a rare 25-homocheilanthane carbon skeleton, while flabelliferin B (2) is a 24-nor-25-homoscalarane sesterterpenoid.
引用
收藏
页码：1490 / 1494
页数：5
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