Menthacarin attenuates experimental colitis

被引：7
|
作者：
Alliger, Korina [1 ]
Khalil, Mohammad [1 ,2 ]
Koenig, Beatrix [3 ]
Weisenburger, Sabrina [3 ]
Koch, Egon [3 ]
Engel, Matthias [1 ]
机构：
[1] Univ Klinikum Erlangen, Dept Med 1, Ulmenweg 18, D-91054 Erlangen, Germany
[2] Inst Physiol & Pathophysiol, Univ Str 17, D-91054 Erlangen, Germany
[3] Dr Willmar Schwabe Pharmaceut, Preclin Res, Willmar Schwabe St 4, D-76227 Karlsruhe, Germany
来源：
PHYTOMEDICINE | 2020年 / 77卷
关键词：
Inflammatory bowel disease; Peppermint; Caraway; Menthacarin; TRPA1; TRPM8; PEPPERMINT OIL; INFLAMMATION; INHIBITION; LIMONENE; DISEASE; ALPHA;
D O I：
10.1016/j.phymed.2020.153212
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Background: Peppermint oil and caraway oil are established remedies in gastroenterological medicine because of their spasmolytic/analgesic effects. Purpose: We investigated whether Menthacarin, a combination of both oils, exerted anti-inflammatory effects in a dextran sodium sulphate (DSS, 2%) murine model of colitis. Study Design and Methods: C57BL/6 mice were orally administered Menthacarin in doses of 10, 30, 60, and 120 mu g/g body weight (BW), and control mice received 0.2% agar, 10 mu l/g BW, during 8 days of DSS-induced colitis. Colitis was monitored by BW measurements and colonoscopies. Colons of euthanised mice were excised for histological staining and ELISA measurements of the cytokines TNF alpha, IL-6, IL-10, IL-1 beta, and TGF-beta. Results: Menthacarin-treated mice compared to controls showed improved macroscopical and microscopical parameters and lower BW loss during the course of colitis. Menthacarin changed the colonic cytokine profile towards a regulatory/anti-inflammatory phenotype. Conclusion: Menthacarin attenuates experimental colitis and may be a promising add-on therapy for the treatment of IBD.
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页数：6
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