DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry

被引：3
|
作者：
Ohira, Kenji [1 ]
Yokota, Hajime [2 ]
Hirano, Shigeki [3 ]
Nishimura, Motoi [4 ]
Mukai, Hiroki [1 ]
Horikoshi, Takuro [1 ]
Sawai, Setsu [3 ]
Yamanaka, Yoshitaka [3 ]
Yamamoto, Tatsuya [5 ]
Kakeda, Shingo [6 ]
Kuwabara, Satoshi [3 ]
Tanaka, Tomoaki [7 ]
Uno, Takashi [2 ]
机构：
[1] Chiba Univ Hosp, Dept Radiol, Chiba, Chiba, Japan
[2] Chiba Univ, Dept Diagnost Radiol & Radiat Oncol, Grad Sch Med, Chiba, Chiba, Japan
[3] Chiba Univ, Grad Sch Med, Dept Neurol, Chiba, Chiba, Japan
[4] Chiba Univ Hosp, Div Lab Med, Chiba, Chiba, Japan
[5] Chiba Prefectural Univ Hlth Sci, Dept Rehabil, Chiba, Chiba, Japan
[6] Hirosaki Univ, Dept Diagnost Radiol, Grad Sch Med, Hirosaki, Aomori, Japan
[7] Chiba Univ, Grad Sch Med, Dept Mol Diag, Chiba, Chiba, Japan
来源：
PARKINSONS DISEASE | 2022年 / 2022卷
关键词：
RECEPTOR GENE POLYMORPHISMS; DOPAMINE D2; COGNITIVE IMPAIRMENT; DIAGNOSTIC-CRITERIA; GRAY-MATTER; A1; ALLELE; ASSOCIATION; LRRK2; DYSFUNCTION; ATROPHY;
D O I：
10.1155/2022/8649195
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Taq1A polymorphism is a DRD2 gene variant located in an exon of the ANKK1 gene and has an important role in the brain's dopaminergic functions. Some studies have indicated that A1 carriers have an increased risk of developing Parkinson's disease (PD) and show poorer clinical performance than A2 homo carriers. Previous studies have suggested that A1 carriers had fewer dopamine D2 receptors in the caudate and increased cortical activity as a compensatory mechanism. However, there is little information about morphological changes associated with this polymorphism in patients with PD. The study's aim was to investigate the relationship between brain volume and Taq1A polymorphism in PD using voxel-based morphometry (VBM). Based on Taq1A polymorphism, 103 patients with PD were divided into two groups: A1 carriers (A1/A1 and A1/A2) and A2 homo carriers (A2/A2). The volume of the left prefrontal cortex (PFC) was significantly decreased in A2 homo carriers compared to A1 carriers. This finding supports the association between Taq1A polymorphism and brain volume in PD and may explain the compensation of cortical function in A1 carriers with PD.
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页数：7
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