Roadmap for new practitioners to navigate the multiple myeloma landscape

被引:0
|
作者
Tam, Tiffany [1 ]
Smith, Eric [1 ]
Lozoya, Evelyn [1 ]
Heers, Hayley [1 ]
Allred, P. Andrew [1 ]
机构
[1] Banner MD Anderson Canc Ctr, 2946 E Banner Gateway Dr, Gilbert, AZ 85295 USA
关键词
Multiple myeloma; Immunomodulators; Proteosome inhibitors; Anti-CD38-targeting antibodies; STEM-CELL TRANSPLANTATION; DOUBLE-BLIND; IMMUNOMODULATORY DRUGS; ZOLEDRONIC ACID; OPEN-LABEL; BORTEZOMIB; PHASE-3; DEXAMETHASONE; MULTICENTER; OUTCOMES;
D O I
10.1016/j.heliyon.2022.e10586
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multiple myeloma (MM) is a blood cancer in which monoclonal plasma cells cause end organ damage resulting in hypercalcemia, renal failure, anemia, and bone lesions. MM is considered incurable, however, recent advances in treatment have improved survival. Historically, MM has been treated with immunomodulatory drugs (IMiDs), proteosome inhibitors (PIs), and corticosteroids. While newer therapeutic approaches such as monoclonal antibodies and cellular therapies have broadened the treatment horizon, the selection and sequencing of these therapies has become more complex. This review aims to help advanced practice providers navigate through the diagnosis, staging, treatment, and supportive care considerations in the MM space.
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页数:10
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