Polymer conjugates with potential biological activity based on new derivatives of 2-mercaptobenzoxazole-synthesis and characterization

被引：0
|
作者：
Aparaschivei, Radita [1 ,2 ]
Sunel, Valeriu [1 ]
Holban, Mihaela [1 ]
Popa, Marcel [2 ]
Desbrieres, Jacques [3 ]
机构：
[1] Alexandru Ioan Cuza Univ, Dept Organ Chem, Fac Chem, Iasi 700506, Romania
[2] Gheorghe Asachi Tech Univ Iasi, Dept Nat & Synthet Polymers, Fac Chem Engn & Environm Protect, Iasi 700050, Romania
[3] Pau & Adour Countries Univ UPPA, IPREM, F-64053 Pau 9, France
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2013年 / 11卷 / 11期
关键词：
2-mercapto-benzoxazole derivatives; Hydrazides; Drug-polymer conjugates; Poly (maleic anhydride-alt-vinyl acetate); DRUG; ANTICANCER; NANOTECHNOLOGY;
D O I：
10.2478/s11532-013-0310-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New potentially biologically active compounds derived from 2-mercapto-benzoxazole were synthesized and coupled on polymeric support of poly (maleic anhydride-alt-vinyl acetate) for the preparation of polymer-drug conjugates with controlled drug release. All compounds were characterized by elemental and spectroscopy (FT-IR, H-1-NMR) analysis. The toxicological tests recommend the products for further laboratory screening.
引用
收藏
页码：1808 / 1815
页数：8
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