Obeticholic acid, a synthetic FXR agonist, prevents hepatic inflammation and fibrosis in a novel mouse model of non-alcoholic steatohepatitis

被引：0
|
作者：
Goto, Toshihiro [1 ,2 ]
Itoh, Michiko [2 ]
Kanai, Sayaka [2 ]
Suganami, Takayoshi [3 ,4 ]
Ogawa, Yoshihiro [2 ,5 ]
机构：
[1] Sumitomo Dainippon Pharma Co Ltd, Drug Dev Res Labs, Osaka, Japan
[2] Tokyo Med & Dent Univ, Tokyo, Japan
[3] Nagoya Univ, Nagoya, Aichi 4648601, Japan
[4] JST PRESTO, Tokyo, Japan
[5] AMED CREST, Tokyo, Japan
来源：
HEPATOLOGY | 2016年 / 64卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1609
引用
收藏
页码：797A / 798A
页数：2
相关论文
共 50 条
  • [11] OBETICHOLIC ACID, AN FXR AGONIST, REDUCES HEPATIC FIBROSIS IN A RAT MODEL OF TOXIC CIRRHOSIS
    Verbeke, L. D.
    Mannaerts, I.
    Schierwagen, R.
    Klein, S.
    Vander Elst, I.
    Windmolders, P.
    Farre, R.
    Wenes, M.
    Mazzone, M.
    Nevens, F.
    van Grunsven, L. A.
    Trebicka, J.
    Laleman, W.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S479 - S479
  • [12] THYROID HORMONE DECREASES HEPATIC STEATOSIS, INFLAMMATION, AND FIBROSIS IN A DIETARY MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
    Zhou, Jin
    HEPATOLOGY, 2020, 72 : 1040 - 1040
  • [13] Amelioration of endoplasmic reticulum stress by 4-phenylbutyric acid prevents hepatic inflammation, fibrosis and carcinogenesis in non-alcoholic steatohepatitis model mice
    Kon, Kazuyoshi
    Ikejima, Kenichi
    Uchiyama, Akira
    Aoyama, Tomonori
    Yamashina, Shunhei
    Watanabe, Sumio
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 : 354 - 354
  • [14] Combination of an ASK1 inhibitor and FXR agonist increases efficacy in a mouse model of non-alcoholic steatohepatitis
    Liles, J. T.
    Zagorska, A.
    Hollenback, D.
    Budas, G. R.
    Liu, H.
    Liu, K.
    Brockett, R.
    Shauf, A.
    Tumas, D.
    Breckenridge, D. G.
    JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S19 - S20
  • [15] A Novel Mouse Model of Accelerated Non-Alcoholic Steatohepatitis
    Malhotra, P.
    Han, E.
    Ooka, K.
    Muthusamy, S.
    Gill, R.
    Dudeja, P.
    Aloman, C.
    Alrefai, W.
    FASEB JOURNAL, 2015, 29
  • [16] Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model
    Hayashida, Momoka
    Hashimoto, Kei
    Ishikawa, Tomoko
    Miyamoto, Yasunori
    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2019, 100 (02) : 72 - 82
  • [17] A mouse model for Non-alcoholic Steatohepatitis
    Sundaresan, Sinju
    Vijayagopal, Parakat
    Mills, Nathaniel
    Imrhan, Victorine
    Prasad, Chandan
    FASEB JOURNAL, 2010, 24
  • [18] Deferasirox prevents progression of non-alcoholic steatohepatitis in a mouse model with inhibition of heaptic fibrosis and hepatocellular ballooning
    Korenaga, Masaaki
    Korenaga, Keiko
    Mizokami, Masashi
    Kanto, Tatsuya
    HEPATOLOGY, 2016, 64 : 785A - 786A
  • [19] Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis
    Kimura, Kumi
    Inaba, Yuka
    Watanabe, Hitoshi
    Matsukawa, Toshiya
    Matsumoto, Michihiro
    Inoue, Hiroshi
    JOURNAL OF DIABETES INVESTIGATION, 2019, 10 (03) : 659 - 666
  • [20] Molecular Mechanisms of Hepatic Fibrosis in Non-Alcoholic Steatohepatitis
    Rombouts, Krista
    Marra, Fabio
    DIGESTIVE DISEASES, 2010, 28 (01) : 229 - 235
12345