Immune system and hepatitis B virus infection

被引：38
|
作者：
Hui, Chee-Kin [1 ,2 ]
Lau, George K. K. [1 ,2 ]
机构：
[1] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Ctr Study Liver Dis, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF CLINICAL VIROLOGY | 2005年 / 34卷
关键词：
Hepatitis B virus; Cytotoxic T lymphocyte; Immune response; Cytokine; Genomic variation;
D O I：
10.1016/S1386-6532(05)80009-5
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The immune system plays an important role in determining the outcome of hepatitis B virus (HBV) infection. This is because recovery from of acute HBV infection is associated with a clear division in the profile of adaptive immune response. Multispecific antiviral CD4 and CD8 responses with a type 1 cytokine production can be observed in patients who recover from acute HBV infection. On the other hand, those who develop chronic infection tend to have a weak virus specific T cell response. Therapeutic strategies aimed at correcting this defective T cell reactivity could represent a complementary approach to the cure of chronic HBV infection. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：S44 / S48
页数：5
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