Dorsal-stream motion processing deficits persist into adulthood in Williams syndrome

被引：73

作者：

Atkinson, J

Braddick, O

Rose, FE

Searcy, YM

Wattam-Bell, J

Bellugi, U

机构：

[1] UCL, Dept Psychol, Visual Dev Unit, London WC1E 6BT, England

[2] Univ Oxford, Dept Expt Psychol, Oxford OX1 2JD, England

[3] Salk Inst Biol Studies, Cognit Neurosci Lab, La Jolla, CA USA

来源：

NEUROPSYCHOLOGIA | 2006年 / 44卷 / 05期

基金：

英国医学研究理事会;

关键词：

Williams syndrome; brain development; motion coherence; form coherence; dorsal stream;

D O I：

10.1016/j.neuropsychologia.2005.08.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous studies of children with Williams syndrome (WS) have found a specific deficit in dorsal cortical stream function, indicated by poor performance in coherence thresholds for motion compared to form. Here we investigated whether this is a transient developmental feature or a persisting aspect of cerebral organization in WS. Motion and form coherence thresholds were tested in a group of 45 WS individuals aged 16-42 years, and 19 normal adult controls. Although there was considerable variation in the coherence thresholds across individuals with WS, the WS group showed overall worse performance than controls. A significant group x threshold condition interaction showed a substantially greater performance deficit for motion than for form coherence in the WS group relative to controls. This result suggests that the motion deficit is an enduring feature in WS and is a marker for one aspect of dorsal-stream vulnerability. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：828 / 833

页数：6