Clinical characteristics and outcomes of tuberculosis in Douala, Cameroon: a 7-year retrospective cohort study
被引:10
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作者:
Ngahane, B. H. Mbatchou
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机构:
Douala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Univ Douala, Fac Med & Pharmaceut Sci, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Ngahane, B. H. Mbatchou
[1
,2
]
Dahirou, F.
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机构:
Douala Gen Hosp, Dept Internal Med, POB 4856, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Dahirou, F.
[1
]
Tchieche, C.
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Tchieche, C.
[3
]
Wandji, A.
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Wandji, A.
[3
]
Ngnie, C.
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Ngnie, C.
[3
]
Nana-Metchedjin, A.
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Nana-Metchedjin, A.
[3
]
Nyankiye, E.
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Nyankiye, E.
[3
]
Mangamba, M. L. Endale
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机构:
Douala Laquintinie Hosp, Resp Dis Unit, Douala, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Mangamba, M. L. Endale
[3
]
Kuaban, C.
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机构:
Univ Bamenda, Fac Hlth Sci, Bamenda, CameroonDouala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
Kuaban, C.
[4
]
机构:
[1] Douala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
[2] Univ Douala, Fac Med & Pharmaceut Sci, Douala, Cameroon
[3] Douala Laquintinie Hosp, Resp Dis Unit, Douala, Cameroon
SETTING: Tuberculosis (TB) clinic, Douala Laquintinie Hospital, Douala, Cameroon. OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes. DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes. RESULTS: Of 8902 TB cases included, 5110 (57.4%) were males. The median age was 33 years. The prevalence of human immunodeficiency virus (HIV) infection was 37.6%, with a significant decline over the study years (P = 0.000). The main clinical form of TB was smear-positive TB (50.5%). The treatment success rate was 75.2%, while the mortality rate was 8.1%. The year of TB diagnosis, retreatment cases, sputum non conversion at the end of month 2, HIV infection and HIV testing not done were associated with death. Retreatment and non-conversion of sputum were associated with treatment failure, while male sex, age, sputum non-conversion, HIV infection and HIV testing not done were associated with loss to follow-up. CONCLUSION: TB management objectives may be attained by focusing specifically on higher risk groups to prevent poor treatment outcomes.
机构:
Northwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Northwestern Univ, Div Organ Transplantat, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USANorthwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Russell, Elliott
Yang, Amy
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机构:
Northwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Northwestern Univ, Div Organ Transplantat, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USANorthwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Yang, Amy
Tardrew, Sydney
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机构:
Northwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Northwestern Univ, Div Organ Transplantat, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USANorthwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Tardrew, Sydney
Ison, Michael G.
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机构:
Northwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA
Northwestern Univ, Div Organ Transplantat, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USANorthwestern Univ, Div Infect Dis, Feinberg Sch Med, 645 N Michigan Ave,Ste 900, Chicago, IL 60611 USA