Clinical characteristics and outcomes of tuberculosis in Douala, Cameroon: a 7-year retrospective cohort study

被引:10
|
作者
Ngahane, B. H. Mbatchou [1 ,2 ]
Dahirou, F. [1 ]
Tchieche, C. [3 ]
Wandji, A. [3 ]
Ngnie, C. [3 ]
Nana-Metchedjin, A. [3 ]
Nyankiye, E. [3 ]
Mangamba, M. L. Endale [3 ]
Kuaban, C. [4 ]
机构
[1] Douala Gen Hosp, Dept Internal Med, POB 4856, Douala, Cameroon
[2] Univ Douala, Fac Med & Pharmaceut Sci, Douala, Cameroon
[3] Douala Laquintinie Hosp, Resp Dis Unit, Douala, Cameroon
[4] Univ Bamenda, Fac Hlth Sci, Bamenda, Cameroon
关键词
epidemiology; tuberculosis; treatment; Cameroon; MORTALITY; GENDER; DEFAULT; ABIDJAN; SEX;
D O I
10.5588/ijtld.15.0731
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
SETTING: Tuberculosis (TB) clinic, Douala Laquintinie Hospital, Douala, Cameroon. OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes. DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes. RESULTS: Of 8902 TB cases included, 5110 (57.4%) were males. The median age was 33 years. The prevalence of human immunodeficiency virus (HIV) infection was 37.6%, with a significant decline over the study years (P = 0.000). The main clinical form of TB was smear-positive TB (50.5%). The treatment success rate was 75.2%, while the mortality rate was 8.1%. The year of TB diagnosis, retreatment cases, sputum non conversion at the end of month 2, HIV infection and HIV testing not done were associated with death. Retreatment and non-conversion of sputum were associated with treatment failure, while male sex, age, sputum non-conversion, HIV infection and HIV testing not done were associated with loss to follow-up. CONCLUSION: TB management objectives may be attained by focusing specifically on higher risk groups to prevent poor treatment outcomes.
引用
收藏
页码:1609 / 1614
页数:6
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