Role of TH17 cytokines in the control of colorectal cancer

被引：106
|
作者：
De Simone, Veronica [1 ]
Pallone, Francesco [1 ]
Monteleone, Giovanni [1 ]
Stolfi, Carmine [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期
关键词：
anti-cytokine therapy; colitis-associated colon cancer; IL-17A; IL-17F; IL-21; IL-22; inflammation; NF kappa B; STAT3; T(H)17 cells; ROR-GAMMA-T; COLON-CANCER; PROMOTES ANGIOGENESIS; TUMOR-GROWTH; TGF-BETA; CELLS; DIFFERENTIATION; COLITIS; IL-22; INTERLEUKIN-21;
D O I：
10.4161/onci.26617
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients. Studies with murine models of CRC have delineated the mechanisms by which T(H)17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs. In this review article, we discuss experimental data supporting the role of T(H)17 cytokines in the modulation of colorectal tumorigenesis.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Th17 Cytokines and the Gut Mucosal Barrier
    Christoph Blaschitz
    Manuela Raffatellu
    Journal of Clinical Immunology, 2010, 30 : 196 - 203
  • [22] BACTERIAL MICROBIOME AND TH17 CYTOKINES IN CRS
    Ramakrishnan, V.
    Kofonow, J.
    Frank, D.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2015, 115 (05) : A30 - A30
  • [23] Role of Th17 cells in head and neck cancer
    Kesselring, R.
    Thiel, A.
    Pries, R.
    Wollenberg, B.
    ORAL ONCOLOGY, 2009, : 209 - 209
  • [24] Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases
    Akhter, Saima
    Tasnin, Farhin Montaha
    Islam, Mohammad Nazmul
    Rauf, Abdur
    Mitra, Saikat
    Emran, Talha Bin
    Alhumaydhi, Fahad A.
    Khalil, Anees Ahmed
    Aljohani, Abdullah S. M.
    Al Abdulmonem, Waleed
    Thiruvengadam, Muthu
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (26) : 2078 - 2090
  • [25] ROLE OF IL-23/TH17 AXIS CYTOKINES IN RHEUMATOID ARTHRITIS
    Meher, J.
    Patel, S.
    Siddiqui, M. S.
    Nanda, R.
    ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 : 1183 - 1183
  • [26] Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer
    Tsvetelina Veselinova Velikova
    Lyuba Miteva
    Noyko Stanilov
    Zoya Spassova
    Spaska Angelova Stanilova
    World Journal of Gastroenterology, 2020, (16) : 1912 - 1925
  • [27] Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer
    Velikova, Tsvetelina Veselinova
    Miteva, Lyuba
    Stanilov, Noyko
    Spassova, Zoya
    Stanilova, Spaska Angelova
    WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (16) : 1912 - 1925
  • [28] Changes of Th17/Treg cell and related cytokines in pancreatic cancer patients
    Wang, Xiaofang
    Wang, Lei
    Mo, Qingjiang
    Dong, Yuqian
    Wang, Guoqiang
    Jia, Ankui
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (05): : 5702 - 5708
  • [29] Th17 cytokines regulate profibrotic cytokines release by human eosinophils
    Rabih Halwani
    Saleh Al Muhsen
    Hamdan Al Jahdali
    Qutayba Hamid
    Allergy, Asthma & Clinical Immunology, 8 (Suppl 1)
  • [30] Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
    Kim, Kyoung-Woon
    Kim, Hae-Rim
    Kim, Bo-Mi
    Cho, Mi-La
    Lee, Sang-Heon
    AMERICAN JOURNAL OF PATHOLOGY, 2015, 185 (11): : 3011 - 3024
12345