Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum

被引：47

作者：

Liu, Shuangzhu ^{[1
]}

Chen, Zhenhua ^{[1
]}

Wu, Jian ^{[1
]}

Wang, Luoyi ^{[1
]}

Wang, Hongmin ^{[1
]}

Zhao, Weimin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China

来源：

PHYTOCHEMISTRY | 2013年 / 93卷

关键词：

Cynanchum auriculatum; Asclepiadaceae; Pregnane glycoside; Appetite suppressant; C-21 STEROIDAL GLYCOSIDES; HOODIA-GORDONII; SUGAR CHAIN; CONSTITUENTS; EXTRACT; PLANT; PAIR;

D O I：

10.1016/j.phytochem.2013.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the search for plant alternatives to Hoodia gordonii containing P57, a pregnane glycoside with potential appetite suppressant effect, the roots of Cynanchum auriculatum were investigated. As a result, 15 pregnane glycosides including nine never previously reported were isolated. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. Appetite suppressant effect and body weight loss were observed when tested with the most abundant pregnane glycoside, wilfoside K1N, in an in vivo test with rats. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：144 / 153

页数：10

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