Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD

被引：17

作者：

Greenblatt, Ethan J. ^{[1
]}

Olzmann, James A. ^{[2
]}

Kopito, Ron R. ^{[2
]}

机构：

[1] Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Inst, Res Labs, Baltimore, MD 21210 USA

[2] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 10期

关键词：

ENDOPLASMIC-RETICULUM; QUALITY-CONTROL; DEGRADATION; MEMBRANE; DOMAIN; DISLOCATION; IRHOM2; TACE;

D O I：

10.1038/nsmb.2398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endoplasmic reticulum-associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the endoplasmic reticulum-resident rhomboid protease RHBDL4 facilitates ERAD by recognizing and cleaving integral membrane substrates. The work indicates that intramembrane proteolysis may have a general role in the extraction of misfolded membrane proteins from the endoplasmic reticulum.

引用

页码：979 / 981

页数：3

共 50 条

[21] Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
Wu, Zhuoru
Yan, Nieng
Feng, Liang
Oberstein, Adam
Yan, Hanchi
Baker, Rosanna P.
Gu, Lichuan
Jeffrey, Philip D.
Urban, Sinisa
Shi, Yigong
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) : 1084 - 1091
[22] Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
Zhuoru Wu
Nieng Yan
Liang Feng
Adam Oberstein
Hanchi Yan
Rosanna P Baker
Lichuan Gu
Philip D Jeffrey
Sinisa Urban
Yigong Shi
Nature Structural & Molecular Biology, 2006, 13 : 1084 - 1091
[23] Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease
Began, Jakub
Cordier, Baptiste
Brezinova, Jana
Delisle, Jordan
Hexnerova, Rozalie
Srb, Pavel
Rampirova, Petra
Kozisek, Milan
Baudet, Mathieu
Coute, Yohann
Galinier, Anne
Veverka, Vaclav
Doan, Thierry
Strisovsky, Kvido
EMBO JOURNAL, 2020, 39 (10):
[24] Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures
Zoll, Sebastian
Stanchev, Stancho
Began, Jakub
Skerle, Jan
Lepsik, Martin
Peclinovska, Lucie
Majer, Pavel
Strisovsky, Kvido
EMBO JOURNAL, 2014, 33 (20): : 2408 - 2421
[25] Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate
Baker, Rosanna P.
Young, Keith
Feng, Liang
Shi, Yigong
Urban, Sinisa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (20) : 8257 - 8262
[26] Making the cut with protease engineering
Dyer, Rebekah P.
Weiss, Gregory A.
CELL CHEMICAL BIOLOGY, 2022, 29 (02) : 177 - 190
[27] An Internal Water-Retention Site in the Rhomboid Intramembrane Protease GlpG Ensures Catalytic Efficiency
Zhou, Yanzi
Moin, Syed M.
Urban, Sinisa
Zhang, Yingkai
STRUCTURE, 2012, 20 (07) : 1255 - 1263
[28] Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins
Battistini, Chiara
Rehman, Michael
Avolio, Marco
Arduin, Alessia
Valdembri, Donatella
Serini, Guido
Tamagnone, Luca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (23)
[29] The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
Schneppenheim, Janna
Dressel, Ralf
Huettl, Susann
Luellmann-Rauch, Renate
Engelke, Michael
Dittmann, Kai
Wienands, Juergen
Eskelinen, Eeva-Liisa
Hermans-Borgmeyer, Irm
Fluhrer, Regina
Saftig, Paul
Schroeder, Bernd
JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (01): : 41 - 58
[30] Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
Grieve, Adam G.
Yeh, Yi-Chun
Chang, Yu-Fen
Huang, Hsin-Yi
Zarcone, Lucrezia
Breuning, Johannes
Johnson, Nicholas
Strisovsky, Kvido
Brown, Marion H.
Parekh, Anant B.
Freeman, Matthew
MOLECULAR CELL, 2021, 81 (23) : 4784 - +

← 1 2 3 4 5 →