Lichenysin-geminal amino acid-based surfactants: Synergistic action of an unconventional antimicrobial mixture

被引:12
|
作者
Coronel-Leon, Jonathan [1 ,3 ]
Pinazo, Aurora [2 ]
Perez, Lourdes [2 ]
Jose Espuny, Ma [1 ]
Ma Marques, Ana [1 ]
Manresa, Angeles [1 ]
机构
[1] Univ Barcelona, Fac Farm, Microbiol Lab, Joan XXIII S-N, E-08028 Barcelona, Spain
[2] IQAC CSIC, Dept Chem & Surfactant Technol, Jordi Girona 18-26, Barcelona 08034, Spain
[3] Escuela Super Politecn Litoral, ESPOL, Fac Ingn Mecan & Ciencias Prod, Campus Gustavo Galindo Km 30-5 Via Perimetral, Guayaquil, Ecuador
关键词
Antimicrobial properties; Lichenysin; Flow cytometry; Transmission electron microscopy; Potassium leakage; Gemini surfactants; Arginine; Listeria nonocytogenes; Escherichia coli; CATIONIC SURFACTANTS; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; ARGININE; AGGREGATION; RHAMNOLIPIDS; PEPTIDE; WATER;
D O I
10.1016/j.colsurfb.2016.10.008
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Recently it has been demonstrated that catanionic mixtures of oppositely charged surfactants have improved physicochemical-biological properties compared to the individual components. Isotherms of mixtures of an anionic biosurfactant (lichenysin) and a cationic aminoacid surfactant (C-3(LA)(2)) indicate a strong interaction suggesting the formation of a new "pseudo-surfactant". The antimicrobial properties of the mixture lichenysin and C-3(LA)(2) M80:20, indicate a synergistic effect of the components. The mechanism of action on the bacterial envelope was assessed by flow cytometry and Transmission Electron Microscopy. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:38 / 47
页数:10
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