Gold-Catalyzed Hydrosilyloxylation Driving Tandem Aldol and Mannich Reactions

被引：22

作者：

Kang, Dongjin ^{[1
]}

Park, Sangjune ^{[1
]}

Ryu, Taekyu ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 15期

基金：

新加坡国家研究基金会;

关键词：

ALLYLIC ALCOHOLS; ASYMMETRIC ALDOL; ISOMERIZATION; CONDENSATION; PLATINUM; ALKYNES; CYCLOADDITION; HETEROCYCLES; CARBOCYCLES; DERIVATIVES;

D O I：

10.1021/ol301660f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemoselective formation of an enolate from alkyne in the presence of a carbonyl and imine group was realized, which constructed a variety of structural motifs under exceedingly mild reaction conditions in a tandem process. Reaction driving tandem hydrosilyloxylation/aldol reactions was achieved through the formation of enol silyl ethers catalytically generated in situ from readily available alkynes. These reactions were expanded to obtain beta-amino enol silyl ethers in good yields via the tandem hydrosilyloxylation/isomerization/Mannich reaction.

引用

页码：3912 / 3915

页数：4

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