Blood-Brain Barrier Dynamics to Maintain Brain Homeostasis

被引：155
|
作者：
Segarra, Marta [1 ,2 ,3 ]
Aburto, Maria R. [1 ,2 ]
Acker-Palmer, Amparo [1 ,2 ,3 ,4 ]
机构：
[1] Buchmann Inst Mol Life Sci BMLS, Neuro & Vasc Guidance, Max von Laue Str 15, D-60438 Frankfurt, Germany
[2] Inst Cell Biol & Neurosci, Max von Laue Str 15, D-60438 Frankfurt, Germany
[3] Cardiopulm Inst CPI, Max von Laue Str 15, D-60438 Frankfurt, Germany
[4] Max Planck Inst Brain Res, Max von Laue Str 4, D-60438 Frankfurt, Germany
来源：
TRENDS IN NEUROSCIENCES | 2021年 / 44卷 / 05期
基金：
欧洲研究理事会;
关键词：
P-GLYCOPROTEIN FUNCTION; OXIDATIVE STRESS; METHAMPHETAMINE INTOXICATION; ENDOTHELIAL-CELLS; BONE-MARROW; PERMEABILITY; SLEEP; EXPRESSION; INTEGRITY; TRANSPORT;
D O I：
10.1016/j.tins.2020.12.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The blood?brain barrier (BBB) is a dynamic platform for exchange of substances between the blood and the brain parenchyma, and it is an essential functional gatekeeper for the central nervous system (CNS). While it is widely recognized that BBB disruption is a hallmark of several neurovascular pathologies, an aspect of the BBB that has received somewhat less attention is the dynamic modulation of BBB tightness to maintain brain homeostasis in response to extrinsic environmental factors and physiological changes. In this review, we summarize how BBB integrity adjusts in critical stages along the life span, as well as how BBB permeability can be altered by common stressors derived from nutritional habits, environmental factors and psychological stress.
引用
收藏
页码：393 / 405
页数：13
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