Review -: GABAA receptors in central nervous system disease:: Anxiety, epilepsy, and insomnia

被引：136
|
作者：
Moehler, Hanns
机构：
[1] Univ Zurich, Inst Pharmacol, CH-8057 Zurich, Switzerland
[2] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Zurich, Switzerland
[3] Coll Helveticum Univ, Zurich, Switzerland
来源：
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2006年 / 26卷 / 5-6期
关键词：
epilepsy; anxiety; insomnia; schizophrenia; GABA(A) receptor subtypes;
D O I：
10.1080/10799890600920035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling spike timing and sculpting neuronal rhythms they play a key role in regulating behavior. GABAergic neurons are highly diverse and operate with a corresponding diversity of GABA(A) receptor subtypes. In this article, the contribution of GABA(A) receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed.
引用
收藏
页码：731 / 740
页数：10
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