Kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) are the most common RCC types. RCC has high immune infiltration levels, and immunotherapy is currently one of the most promising treatments for RCC. Collagen triple helix repeat containing 1 (CTHRC1) is an extracellular matrix protein that regulates tumor invasion and modulates the tumor microenvironment. However, the association of CTHRC1 with the prognosis and tumor-infiltrating lymphocytes of KIRP and KIRC has not been reported. We examined the CTHRC1 expression differences in multiple tumor tissues and normal tissues via exploring TIMER, Oncomine, and UALCAN databases. Then, we searched the Kaplan-Meier plotter database to evaluate the correlation of CTHRC1 mRNA level with clinical outcomes. Subsequently, the TIMER platform and TISIDB website were chosen to assess the correlation of CTHRC1 with tumor immune cell infiltration level. We further explored the causes of aberrant CTHRC1 expression in tumorigenesis. We found that CTHRC1 level was significantly elevated in KIRP and KIRC tissues relative to normal tissues. CTHRC1 expression associates with tumor stage, histology, lymph node metastasis, and poor clinical prognosis in KIRP. The CTHRC1 level correlates to tumor grade, stage, nodal metastasis, and worse survival prognosis. Additionally, CTHRC1 is positively related to different tumor-infiltrating immune cells in KIRP and KIRC. Moreover, CTHRC1 was closely correlated with the gene markers of diverse immune cells. Also, high CTHRC1 expression predicted a worse prognosis in KIRP and KIRC based on immune cells. Copy number variations (CNV) and DNA methylation might contribute to the abnormal upregulation of CTHRC1 in KIRP and KIRC. In conclusion, CTHRC1 can serve as a biomarker to predict the prognosis and immune infiltration in KIRP and KIRC.
机构:
Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Bai, Jianrong
Zheng, Axiu
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Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Zheng, Axiu
Ha, Yanping
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Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Ha, Yanping
Xu, Xiaoqing
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Hainan Med Univ, Canc Inst, Haikou, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Xu, Xiaoqing
Yu, Yaping
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Hainan Med Univ, Canc Inst, Haikou, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Yu, Yaping
Lu, Yanda
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Hainan Med Univ, Canc Inst, Haikou, Peoples R China
Hainan Med Univ, Affiliated Hosp 1, Dept Oncol, Haikou, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Lu, Yanda
Zheng, Shaojiang
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Hainan Med Univ, Canc Inst, Haikou, Peoples R China
Hainan Med Univ, Affiliated Hosp 1, Dept Oncol, Haikou, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Zheng, Shaojiang
Shen, Zhihua
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Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Shen, Zhihua
Luo, Botao
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Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Luo, Botao
Jie, Wei
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Guangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
Hainan Med Univ, Canc Inst, Haikou, Peoples R China
Hainan Med Univ, Affiliated Hosp 1, Dept Oncol, Haikou, Peoples R ChinaGuangdong Med Univ, Pathol Diag & Res Ctr, Sch Basic Med Sci, Dept Pathol,Affiliated Hosp, Zhanjiang, Peoples R China
机构:
Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Yao, Wentao
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Liu, Hanyuan
Xu, Feng
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Xu, Feng
Cai, Zhenyu
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Cai, Zhenyu
Hang, Lijing
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Hang, Lijing
Lu, Mingya
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Lu, Mingya
Zhao, Yuan
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Zhao, Yuan
Yang, Chendi
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Nanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
Yang, Chendi
Zong, Yang
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Nanjing Univ Chinese Med, Lab Clin Pharm Tradit Chinese Med, Suzhou TCM Hosp, Suzhou, Peoples R ChinaNanjing Univ Chinese Med, Dept Urol, Suzhou TCM Hosp, Suzhou, Peoples R China
机构:
Wenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Lishui Univ, Lishui City Peoples Hosp, Affiliated Hosp 1, Lishui, Zhejiang, Peoples R ChinaWenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Li, Peng
Xu, Qiangqiang
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Wenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Lishui Univ, Lishui City Peoples Hosp, Affiliated Hosp 1, Lishui, Zhejiang, Peoples R ChinaWenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Xu, Qiangqiang
Liu, Ken
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Wenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Lishui Univ, Lishui City Peoples Hosp, Affiliated Hosp 1, Lishui, Zhejiang, Peoples R ChinaWenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Liu, Ken
Ye, Junjie
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Wenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
Lishui Univ, Lishui City Peoples Hosp, Affiliated Hosp 1, Lishui, Zhejiang, Peoples R ChinaWenzhou Med Univ, Lishui City Peoples Hosp, 6th Affiliated Hosp, Lishui, Zhejiang, Peoples R China
机构:
Nanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Fang, Jiayu
Zhen, Jing
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Zhen, Jing
Gong, Yiyang
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Gong, Yiyang
Ke, Yun
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Ke, Yun
Fu, Bidong
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Fu, Bidong
Jiang, Yike
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Jiang, Yike
Xie, Jing
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Xie, Jing
Liu, Yue
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Liu, Yue
Ding, Yongqi
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Nanchang Univ, Coll Clin Med 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Ding, Yongqi
Huang, Da
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Nanchang Univ, Dept Thyroid Surg, Affiliated Hosp 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China
Huang, Da
Xiao, Fan
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Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 2, Nanchang, Peoples R ChinaNanchang Univ, Affiliated Hosp 2, Nanchang, Peoples R China