New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum

被引：7
|
作者：
Jiang, Chunjiao [1 ]
Ji, Jiancheng [1 ]
Li, Peihai [2 ]
Liu, Wenfeng [3 ]
Yu, Hao [1 ]
Yang, Xiuqing [1 ]
Xu, Lili [1 ]
Guo, Lizhong [1 ]
Fan, Yaqin [1 ,3 ]
机构：
[1] Qingdao Agr Univ, Coll Life Sci, Shandong Prov Key Lab Appl Mycol, Qingdao, Peoples R China
[2] Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan, Peoples R China
[3] Minist Nat Resources, Key Lab Sci & Technol Marine Ecol & Environm, Inst Oceanog 1, Qingdao, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 06期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Lanostane-type triterpenoids; Ganoderma applanatum; proangiogenic activity; ALKALOIDS; BODIES;
D O I：
10.1080/14786419.2021.1898388
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new lanostane-type triterpenoids, ganoderenicfys A (1) and B (2), together with six related known terpenoids (3-8), were isolated and identified from the fruiting body of Ganoderma applanatum. The structures of these compounds were established on the basis of detailed interpretation of their NMR and HRESIMS data. The absolute configurations of 1 and 2 were determined by quantum chemical electronic circular dichroism (ECD) calculations. All of the isolated compounds were evaluated for their proangiogenic activities in a transgenic fluorescent zebrafish model. Compounds 1-6 displayed dose-dependently proangiogenic activity in a PTK787-induced vascular injury zebrafish model, while compounds 1, 2 and 4 significantly promoted the angiogenesis. This is the first report for proangiogenic activities of lanostane-type triterpenoids.
引用
收藏
页码：1529 / 1535
页数：7
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