Circadian variation in cell-adhesion molecule expression by normal human leukocytes

被引:26
|
作者
Niehaus, GD
Ervin, E
Patel, A
Khanna, K
Vanek, VW
Fagan, DL
机构
[1] NE Ohio Univ, Coll Med, Dept Physiol, Rootstown, OH 44272 USA
[2] Youngstown State Univ, Dept Biol Sci, Youngstown, OH 44555 USA
[3] St Elizabeth Hosp, Dept Surg, Youngstown, OH 44555 USA
关键词
CD11a; CD62L; CD54; leukocytes; circadian rhythm;
D O I
10.1139/Y02-121
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced transmembrane signal transduction. Since some leukocyte-mediated immune functions exhibit nocturnal intensification, the current study was conducted to investigate the hypothesis that expression of selected cell adhesion molecules (CAM) varies with circadian periodicity. Blood was collected from normal human donors over a 24-h period and CAM expression by monocytes, neutrophils, and lymphocytes evaluated by monoclonal antibody binding and flow cytometry. All leukocyte classes exhibited significant circadian-like variation (p < 0.05) in CD62L (L-selectin) expression. Similarly, a diurnal variation (p < 0.05) in monocyte and neutrophil CD54 (ICAM-1) was observed. Finally, neutrophils demonstrated a circadian-like variation (p < 0.05) in CD11A (LFA-1a). The rhythmic alterations in CAM expression may be clinically relevant, since changes in CAM expression have the potential to modulate the leukocyte-induced pathogenesis associated with disease progressions such as nocturnal asthma, the nighttime exacerbations of rheumatoid arthritis, and the high nocturnal incidence of cerebrovascular and cardiovascular crisis.
引用
收藏
页码:935 / 940
页数:6
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