Design and synthesis of artificial ribonucleases based on 1,4-diazabicyclo[2.2.2]octane and imidazole

被引：1

作者：

Konevetz, DA

Beck, IE

Shishkin, GV

Vlassov, VV

Silnikov, VN

机构：

[1] Russian Acad Sci, Novosibirsk Inst Bioorgan Chem, Novosibirsk 630090, Russia

[2] Russian Acad Sci, GK Boreskov Inst Catalysis, Novosibirsk 630090, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2002年 / 51卷 / 07期

基金：

俄罗斯基础研究基金会; 英国惠康基金;

关键词：

artificial ribonucleases; simulation of enzyme catalytic sites; RNA hydrolysis; catalysis;

D O I：

10.1023/A:1020937505019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The review surveys the results of our studies devoted to the design of highly efficient catalysts of hydrolysis of the phosphodiester bonds in RNA. These catalysts contain the imidazole residue in the catalytic domain, one or several bis-quaternized rings of 1,4-diaza-bicyclo[2.2.2]octane as a polycationic RNA-binding domain, and a lipophilic radical. A versatile approach to artificial ribonucleases of this type was proposed, which allows one to vary not only the number of positive charges in the RNA-binding domain, the structure of the catalytic site, and their mutual arrangement but also the domain structure of the molecule as a whole. Analysis of the catalytic properties of the synthesized constructs makes it possible to optimize the domain structure and the geometry of the molecule ensuring its maximum ribonuclease activity.

引用

页码：1100 / 1111

页数：12

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