Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines

被引：12
|
作者：
Burgey, Christopher S. [1 ]
Potteiger, Craig M. [1 ]
Deng, James Z. [1 ]
Mosser, Scott D. [2 ]
Salvatore, Christopher A. [2 ]
Yu, Sean [3 ]
Roller, Shane [3 ]
Kane, Stefanie A. [2 ]
Vacca, Joseph P. [1 ]
Williams, Theresa M. [1 ]
机构：
[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA
[2] Merck Res Labs, Dept Pain & Migraine Res, West Point, PA 19486 USA
[3] Merck Res Labs, Dept Drug Metab, West Point, PA 19486 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 22期
关键词：
CGRP; CGRP receptor antagonists; Migraine; Calcitonin gene-related peptide; MIGRAINE; MK-0974; POTENT;
D O I：
10.1016/j.bmcl.2009.09.066
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6368 / 6372
页数：5
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