Rh(III)-Catalyzed Sequential C-H Amination/Annulation Cascade Reactions: Synthesis of Multisubstituted Benzimidazoles

被引：41

作者：

Huang, Siqi ^{[1
]}

Li, Huan ^{[1
]}

Sun, Xiangying ^{[2
]}

Xu, Linhua ^{[1
]}

Wang, Lianhui ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Sch Biomed Sci, Engn Res Ctr Mol Med,Minist Educ, Key Lab Fujian Mol Med,Key Lab Xiamen Marine & Ge, Xiamen 361021, Fujian, Peoples R China

[2] Huaqiao Univ, Sch Mat Sci, Xiamen 361021, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

关键词：

N BOND FORMATION; RHODIUM(III)-CATALYZED SYNTHESIS; CATALYZED DIRECT; 4+2 ANNULATION; O BOND; ACTIVATION; ALKYNES; ACCESS; ANTHRANILS; FACILE;

D O I：

10.1021/acs.orglett.9b01902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical method to construct benzimidazoles via Rh(III)-catalyzed sequential C-H amination and annulation cascade reaction has been developed. The cascade reaction displays high step, atom, and redox economy, is compatible with the air, and has good functional group tolerance and high efficiency. The titled products can be easily further converted into imidazo[4,5-c]acridines, which were observed unique fluorescent properties.

引用

页码：5570 / 5574

页数：5

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