Cleavage at Arg740 appears essential for thrombin-catalyzed cleavage at Arg372 during the activation of factor VIII.

被引：0

作者：

Newell, Jennifer ^{[1
]}

Fay, Philip J. ^{[1
]}

机构：

[1] Univ Rochester, Rochester, NY USA

来源：

BLOOD | 2006年 / 108卷 / 11期

关键词：

D O I：

10.1182/blood.V108.11.1692.1692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1692

引用

页码：482A / 482A

页数：1

共 36 条

[31] FACTOR-VIII-EAST HARTFORD (ARG 1689 CYS) ACTIVITY IS ENHANCED BY CHEMICALS THAT LEAD TO THROMBIN CLEAVAGE OR DISSOCIATION FROM VONWILLEBRAND-FACTOR
ALY, AM
HOYER, LW
THROMBOSIS AND HAEMOSTASIS, 1991, 65 (06) : 942 - 942
[32] FUNCTIONAL-ROLE OF THE POLYSACCHARIDE COMPONENT OF RABBIT THROMBOMODULIN PROTEOGLYCAN - EFFECTS ON INACTIVATION OF THROMBIN BY ANTITHROMBIN, CLEAVAGE OF FIBRINOGEN BY THROMBIN AND THROMBIN-CATALYZED ACTIVATION OF FACTOR-V
BOURIN, MC
LINDAHL, U
BIOCHEMICAL JOURNAL, 1990, 270 (02) : 419 - 425
[33] A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity
Basavaraj, Manjunath Goolyam
Krishnaswamy, Sriram
BLOOD, 2020, 136
[34] Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg 1689
Nakajima, Yuto
Minami, Hiroaki
Nogami, Keiji
THROMBOSIS AND HAEMOSTASIS, 2021, 121 (10) : 1274 - 1288
[35] Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Novel Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689
Nakajima, Yuto
Nogami, Keiji
Minami, Hiroaki
Sasai, Kana
Shima, Midori
BLOOD, 2019, 134
[36] CHARACTERIZATION OF A THROMBIN CLEAVAGE SITE MUTATION (ARG 1689 TO CYS) IN THE FACTOR-VIII GENE OF 2 UNRELATED PATIENTS WITH CROSS-REACTING MATERIAL-POSITIVE HEMOPHILIA-A
ARAI, M
HIGUCHI, M
ANTONARAKIS, SE
KAZAZIAN, HH
PHILLIPS, JA
JANCO, RL
HOYER, LW
BLOOD, 1990, 75 (02) : 384 - 389

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