Extracellular matrix and traumatic brain injury

被引：87

作者：

George, Naijil ^{[1
]}

Geller, Herbert M. ^{[1
]}

机构：

[1] NHLBI, Lab Dev Neurobiol, Cell Biol & Physiol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2018年 / 96卷 / 04期

关键词：

hyaluronan; laminin; metalloprotease; proteoglycans; tenascin; CHONDROITIN SULFATE PROTEOGLYCANS; SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; CORTICAL IMPACT INJURY; TOLL-LIKE RECEPTORS; NEURAL STEM-CELLS; ADULT-RAT BRAIN; NEURITE OUTGROWTH;

D O I：

10.1002/jnr.24151

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.

引用

页码：573 / 588

页数：16

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