Energy-based advection modelling using bond graphs

被引：3
|
作者：
Gawthrop, Peter J. [1 ]
Pan, Michael [1 ,2 ]
机构：
[1] Univ Melbourne, Sch Math & Stat, Dept Biomed Engn, Syst Biol Lab, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Fac Sci, Sch Math & Stat, Melbourne, Vic 3010, Australia
来源：
JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2022年 / 19卷 / 195期
基金：
澳大利亚研究理事会;
关键词：
systems biology; advection; physiome; bond graph; MATHEMATICAL-MODEL; MULTISCALE; FLOW; METABOLISM; TRANSPORT; SYSTEMS;
D O I：
10.1098/rsif.2022.0492
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Advection, the transport of a substance by the flow of a fluid, is a key process in biological systems. The energy-based bond graph approach to modelling chemical transformation within reaction networks is extended to include transport and thus advection. The approach is illustrated using a simple model of advection via circulating flow and by a simple pharmacokinetic model of anaesthetic gas uptake. This extension provides a physically consistent framework for linking advective flows with the fluxes associated with chemical reactions within the context of physiological systems in general and the human physiome in particular.
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收藏
页数：10
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