Solid-phase synthesis of thrombin inhibitors

被引：14

作者：

Lange, UEW ^{[1
]}

Zechel, C ^{[1
]}

机构：

[1] BASF AG, D-67056 Ludwigshafen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00251-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A newly developed convergent solid-phase synthesis provides efficient access to thrombin inhibitors of the D-Phe-Pro-Arg type. Members of the synthesized libraries inhibited thrombin with IC(50)s in the nanomolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1571 / 1573

页数：3

共 50 条

[31] Solid-phase synthesis of glycopeptides
Zang Fa
Liu Gang
PROGRESS IN CHEMISTRY, 2006, 18 (05) : 579 - 600
[32] Solid-phase synthesis of oximes
Hajipour, AR
Mohammadpoor-Baltork, I
Nikbaghat, K
Imanzadeh, G
SYNTHETIC COMMUNICATIONS, 1999, 29 (10) : 1697 - 1701
[33] Solid-phase synthesis of benzimidazoles
Mayer, JP
Lewis, GS
McGee, C
Bankaitis-Davis, D
TETRAHEDRON LETTERS, 1998, 39 (37) : 6655 - 6658
[34] SOLID-PHASE SYNTHESIS OF APAMIN
GRANIER, C
VANRIETSCHOTEN, J
ROCHAT, H
LISSITZKY, S
MIRANDA, F
BULLETIN DE L INSTITUT PASTEUR, 1976, 74 (01): : 51 - 55
[35] Solid-phase synthesis for a lifetime
Gutte, Bernd
BIOPOLYMERS, 2008, 90 (03) : 214 - 214
[36] Solid-phase synthesis of ferrocenylchalcone
Liu, WY
Xu, QH
Chen, BH
Ma, YX
SYNTHETIC COMMUNICATIONS, 2002, 32 (02) : 171 - 174
[37] Solid-Phase Synthesis of Megamolecules
Kimmel, Blaise R.
Modica, Justin A.
Parker, Kelly
Dravid, Vinayak
Mrksich, Milan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (10) : 4534 - 4538
[38] SOLID-PHASE SYNTHESIS OF OLIGORIBONUCLEOTIDES
XU, YZ
LEHMANN, C
SLIM, G
CHRISTODOULOU, C
TAN, ZK
GAIT, MJ
SIXTEENTH SYMPOSIUM ON NUCLEIC ACIDS CHEMISTRY, 1989, 21 : 39 - 40
[39] Solid-Phase Synthesis of Allosamidin
Huang, Gang Liang
Dai, Yue Peng
SYNLETT, 2010, (10) : 1554 - 1556
[40] Solid-phase dendrimer synthesis
Wells, NJ
Basso, A
Bradley, M
BIOPOLYMERS, 1998, 47 (05) : 381 - 396

← 1 2 3 4 5 →