Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II)

被引：2
|
作者：
Na, Yu-Ran [1 ,2 ]
Woo, Dustin J. [1 ,3 ]
Choo, Hyunah [3 ,4 ]
Chung, Hak Suk [1 ,3 ]
Yang, Eun Gyeong [1 ,3 ]
机构：
[1] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 136791, South Korea
[2] Korea Univ, Res Inst Nat Sci, Dept Chem, Seoul 136701, South Korea
[3] Korea Univ Sci & Technol UST, Dept Biol Chem, Seoul 136791, South Korea
[4] Korea Inst Sci & Technol, Ctr Neuromed, Brain Sci Inst, Seoul 136791, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 53期
关键词：
ERYTHROPOIETIN GENE; HIF-ALPHA; FACTOR-I; BINDING; DESFERRIOXAMINE; COPPER;
D O I：
10.1039/c5cc02143j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein that Zn(II) selectively inhibits the hypoxia- inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.
引用
收藏
页码：10730 / 10733
页数：4
相关论文
共 50 条
  • [41] Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation
    Walmsley, S. R.
    Chilvers, E. R.
    Thompson, A.
    Vaughan, K.
    Marriott, H.
    Parker, L.
    Shaw, G.
    Parmar, S.
    Schneider, M.
    Sabroe, I.
    Dockrell, D.
    Milo, M.
    Taylor, C. T.
    Johnson, R.
    Pugh, C.
    Ratcliffe, P.
    Maxwell, P.
    Carmeliet, P.
    Whyte, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [42] Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance
    Liao, Qian
    Deng, Hongyan
    Wang, Zixuan
    Yu, Guangqing
    Zhu, Chunchun
    Jia, Shuke
    Liu, Wen
    Bai, Yao
    Sun, Xueyi
    Chen, Xiaoyun
    Xiao, Wuhan
    Liu, Xing
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (12)
  • [43] The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin
    Masson, N
    Appelhoff, RJ
    Tuckerman, JR
    Tian, Y
    Demol, H
    Puype, M
    Vandekerckhove, J
    Ratcliffe, PJ
    Pugh, CW
    FEBS LETTERS, 2004, 570 (1-3) : 166 - 170
  • [44] An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α
    Koivunen, Peppi
    Tiainen, Paeivi
    Hyvarinen, Jaana
    Williams, Kim E.
    Sormunen, Raija
    Klaus, Stephen J.
    Kivirikko, Kari I.
    Myllyharju, Johanna
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (42) : 30544 - 30552
  • [45] Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia
    Liu, Ping
    Wang, Liping
    DuBois, Byron G.
    Colandrea, Vincent J.
    Liu, Rongqiang
    Cai, Jiaqiang
    Du, Xiaoxing
    Quan, Weiro
    Morris, William
    Bai, Jianwu
    Bishwokarma, Bimjhana
    Cheng, Mangeng
    Piesvaux, Jennifer
    Ray, Kallol
    Alpert, Carla
    Chiu, Chi-Sung
    Zielstorff, Mark
    Metzger, Joseph M.
    Yang, Liming
    Leung, Dennis
    Alleyne, Candice
    Vincent, Stella H.
    Pucci, Vincenzo
    Li, Xiaofang
    Crespo, Alejandro
    Stickens, Dominique
    Hale, Jeffrey J.
    Ujjainwalla, Feroze
    Sinz, Christopher J.
    ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (12): : 1193 - 1198
  • [46] The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential
    Lee, KangAe
    Lynd, Jeremy D.
    O'Reilly, Sandra
    Kiupel, Matti
    McCormick, J. Justin
    LaPres, John J.
    MOLECULAR CANCER RESEARCH, 2008, 6 (05) : 829 - 842
  • [47] Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
    Kozlova, Nina
    Wottawa, Marieke
    Katschinski, Doerthe Magdalena
    Kristiansen, Glen
    Kietzmann, Thomas
    ONCOTARGET, 2017, 8 (06) : 9885 - 9898
  • [48] Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Heart Failure with Preserved Ejection Fraction
    Imamura, Teruhiko
    Hori, Masakazu
    Tanaka, Shuhei
    Kinugawa, Koichiro
    MEDICINA-LITHUANIA, 2021, 57 (12):
  • [49] Impact of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Renal Function in Patient with Heart Failure
    Imamura, Teruhiko
    Ueno, Yohei
    Kinugawa, Koichiro
    JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2021, 8 (12)
  • [50] Daprodustat: A Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia of Chronic Kidney Disease
    Johnson, Haley N.
    Prasad-Reddy, Lalita
    ANNALS OF PHARMACOTHERAPY, 2025, 59 (01) : 71 - 80
12345