TCF-1 and LEF-1 help launch the TFH program

被引：3
|
作者：
Kubo, Masato [1 ,2 ]
机构：
[1] Tokyo Univ Sci, Res Inst Biomed Sci, Chiba, Japan
[2] RIKEN, Ctr Integrat Med Sci IMS, Yokohama, Kanagawa, Japan
来源：
NATURE IMMUNOLOGY | 2015年 / 16卷 / 09期
关键词：
CELL DIFFERENTIATION; PATHWAY; FATE;
D O I：
10.1038/ni.3254
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Follicular helper T cells (T-FH cells) differentiate from naive T cells, but the picture of this differentiation process remains incomplete. Two studies now identify the related transcriptional regulators TCF-1 and LEF-1 as important early participants in this process.
引用
收藏
页码：900 / 901
页数：2
相关论文
共 50 条
  • [41] Loss of expression of the WNT/β-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas
    Dorfman, DM
    Greisman, HA
    Shahsafaei, A
    AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (05): : 1539 - 1544
  • [42] LEF-1 expression in basal cell carcinomas
    Kriegl, L.
    Horst, D.
    Kirchner, T.
    Jung, A.
    BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (06) : 1353 - 1356
  • [43] Critical involvement of Tcf-1 in expansion of thymocytes
    Schilham, MW
    Wilson, A
    Moerer, P
    Benaissa-Trouw, BJ
    Cumano, A
    Clevers, HC
    JOURNAL OF IMMUNOLOGY, 1998, 161 (08): : 3984 - 3991
  • [44] Usefulness of LEF-1 Immunostaining for the Diagnosis of Matricoma
    Reymundo-Jimenez, A.
    Martos-Cabrera, L.
    Munoz-Hernandez, P.
    Llamas-Velascoa, M.
    ACTAS DERMO-SIFILIOGRAFICAS, 2022, 113 (09): : T907 - T910
  • [45] CIRCUMVENTION OF TOLERANCE FOR THE NUCLEAR T-CELL PROTEIN TCF-1 BY IMMUNIZATION OF TCF-1 KNOCK-OUT MICE
    CASTROP, J
    VERBEEK, S
    HOFHUIS, F
    CLEVERS, H
    IMMUNOBIOLOGY, 1995, 193 (2-4) : 281 - 287
  • [46] Expression of LEF-1 and β-Catenin: Is There a Role for LEF-1 in Differentiating Colorectal Adenocarcinoma from Gastric and Pancreatic Adenocarcinoma, and Hepatocellular Carcinoma?
    Avadhani, Vaidehi
    Cohen, Cynthia
    Jiang, Wanhong
    Siddiqui, Momin
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2016, 146 : S126 - S126
  • [47] Tcf-1 expression during Xenopus development
    Roël, G
    van den Broek, O
    Spieker, N
    Peterson-Maduro, J
    Destrée, O
    GENE EXPRESSION PATTERNS, 2003, 3 (02) : 123 - 126
  • [48] TCF-1 takes HEB up a Notch
    Harly, Christelle
    Ciucci, Thomas
    NATURE IMMUNOLOGY, 2018, 19 (12) : 1283 - 1285
  • [49] TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma
    Xu, Xiaolong
    Tang, Xiaodong
    Guo, Wei
    Yang, Kang
    Ren, Tingting
    TUMOR BIOLOGY, 2016, 37 (10) : 14129 - 14140
  • [50] TCF-1 takes HEB up a Notch
    Christelle Harly
    Thomas Ciucci
    Nature Immunology, 2018, 19 : 1283 - 1285
12345