Alcohol-induced brain deficit in alcohol dependence

被引:4
|
作者
Wang, Yanping [1 ]
Sun, Bo [2 ]
机构
[1] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Neurosurg, Huaian, Peoples R China
[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Neurol, Huaian, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2022年 / 13卷
关键词
alcohol dependence; percent amplitude of fluctuation; receiver operating characteristic; cerebellar-visual-orbitofrontal circuit; functional MRI; DEFAULT-MODE NETWORK; FUNCTIONAL CONNECTIVITY; GENDER-DIFFERENCES; SLEEP-DEPRIVATION; DRUG-ADDICTION; PATTERN; REWARD; DYSREGULATION; DISRUPTION; INSIGHTS;
D O I
10.3389/fneur.2022.1036164
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Although numerous adverse effects of alcohol addiction on health, behavior, and brain function were widely reported, the neurobiological mechanism of alcohol dependence remains largely unknown. In this study, a total of twenty-nine patients with alcohol dependence and twenty-nine status-matched normal controls (NCs) were recruited. Percent amplitude of fluctuation (PerAF) was applied to identify alcohol-related brain activity deficits. We found that alcohol dependence was associated with widespread differences in the left orbitofrontal cortex, right higher visual cortex, right supramarginal gyrus, right postcentral gyrus, and bilateral cerebellum posterior lobe with decreased PerAF, but no brain areas with increased PerAF differences were found. ROC curve showed that decreased PerAF revealed extremely high discriminatory power with a high AUC value of 0.953, as well as a high degree of sensitivity (96.6%) and specificity (86.2%), in distinguishing patients with alcohol dependence from NCs. In the alcohol dependence group, the amount of daily alcohol consumption showed significant negative correlations with the right cerebellum posterior lobe and right higher visual cortex. These findings suggest that the cerebellar-visual-orbitofrontal circuit was disturbed by alcohol dependence. The proposed new method of PerAF may be served as a potential biomarker to identify the regional brain activity deficits of alcohol dependence.
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页数:9
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