The Potential of Stem Cells in the Treatment of Skeletal Muscle Injury and Disease

被引:8
|
作者
MacLean, S. [1 ]
Khan, W. S. [2 ]
Malik, A. A. [3 ]
Anand, S. [4 ]
Snow, M. [5 ]
机构
[1] Univ Manchester, Manchester M13 9PL, Lancs, England
[2] Royal Natl Orthopaed Hosp, Inst Orthpaed & Musculoskeletal Sci, Stanmore HA7 4LP, Middx, England
[3] Royal Natl Orthopaed Hosp, Spinal Deform Unit, Stanmore HA7 4LP, Middx, England
[4] Stepping Hill Hosp, Stockport SK2 7JE, Lancs, England
[5] Royal Natl Orthopaed Hosp, Dept Sports Inury, Birmingham B31 2AP, W Midlands, England
关键词
SHOW ENHANCED CHONDROGENESIS; STRESS URINARY-INCONTINENCE; RETRACTED ARTICLE. SEE; INFRAPATELLAR FAT PAD; PERICYTE MARKER 3G5; 1-YEAR FOLLOW-UP; MYOBLAST TRANSFER; SATELLITE CELL; AUTOLOGOUS MYOBLASTS; MUSCULAR-DYSTROPHY;
D O I
10.1155/2012/282348
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Tissue engineering is a pioneering field with huge advances in recent times. These advances are not only in the understanding of how cells can be manipulated but also in potential clinical applications. Thus, tissue engineering, when applied to skeletal muscle cells, is an area of huge prospective benefit to patients with muscle disease/damage. This could include damage to muscle from trauma and include genetic abnormalities, for example, muscular dystrophies. Much of this research thus far has been focused on satellite cells, however, mesenchymal stem cells have more recently come to the fore. In particular, results of trials and further research into their use in heart failure, stress incontinence, and muscular dystrophies are eagerly awaited. Although no doubt, stem cells will have much to offer in the future, the results of further research still limit their use.
引用
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页数:9
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