SMALL-MOLECULE INHIBITORS bULKing up mTOR inhibition

被引：1
|
作者：
Goodwin, Jonathan M. [1 ]
Murphy, Leon O. [1 ]
机构：
[1] Novartis Inst BioMed Res, Cambridge, MA 02139 USA
来源：
NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 10期
关键词：
DIRECT PHOSPHORYLATION; IN-VIVO; AUTOPHAGY; KINASE; TARGET; VPS34; ULK1;
D O I：
10.1038/nchembio.1909
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new small-molecule inhibitor of the autophagy-initiating kinase ULK1 serves to block a critical survival mechanism activated upon inhibition of mTORC1, potentially enhancing treatment efficacy for mTOR inhibitors currently in clinical trials for cancer treatment.
引用
收藏
页码：758 / 760
页数：4
相关论文
共 50 条
  • [41] Small-molecule tyrosine kinase inhibitors as radiosensitizers
    Lawrence, TS
    Nyati, MK
    SEMINARS IN RADIATION ONCOLOGY, 2002, 12 (03) : 33 - 36
  • [42] An overview of small-molecule inhibitors of VEGFR signaling
    Ivy, S. Percy
    Wick, Jeannette Y.
    Kaufman, Bennett M.
    NATURE REVIEWS CLINICAL ONCOLOGY, 2009, 6 (10) : 569 - 579
  • [43] Small-molecule bromodomain inhibitors for cancer therapy
    Qi, Jun
    Filippakopoulos, Panagis
    Picaud, Sarah
    Smith, William
    Keates, Tracy
    Morse, Elizabeth
    Philpott, Martin
    Shaw, Katharin
    Fedorov, Oleg
    West, Nathan
    Heightman, Tom
    French, Christopher
    Knapp, Stefan
    Bradner, James
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [44] Targeting Tumor Microenvironment by Small-Molecule Inhibitors
    Zhong, Shangwei
    Jeong, Ji-Hak
    Chen, Zhikang
    Chen, Zihua
    Luo, Jun-Li
    TRANSLATIONAL ONCOLOGY, 2020, 13 (01): : 57 - 69
  • [45] Small-Molecule Inhibitors of NADPH Oxidase 4
    Borbely, Gabor
    Szabadkai, Istvan
    Horvath, Zoltan
    Marko, Peter
    Varga, Zoltan
    Breza, Nora
    Baska, Ferenc
    Vantus, Tibor
    Huszar, Monika
    Geiszt, Miklos
    Hunyady, Laszlo
    Buday, Laszlo
    Orfi, Laszlo
    Keri, Gyoergy
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (18) : 6758 - 6762
  • [46] Small-Molecule Inhibitors: Disrupting enzyme fluidity
    Anand, Ganesh Srinivasan
    ELIFE, 2021, 10
  • [47] Small-molecule inhibitors of JC polyomavirus infection
    Yatawara, Achani
    Gaidos, Gabriel
    Rupasinghe, Chamila N.
    O'Hara, Bethany A.
    Pellegrini, Maria
    Atwood, Walter J.
    Mierke, Dale F.
    JOURNAL OF PEPTIDE SCIENCE, 2015, 21 (03) : 236 - 242
  • [48] Small-molecule inhibitors of sFRP1
    Zheng, Jie
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
  • [49] Small-molecule inhibitors of ferrochelatase are antiangiogenic agents
    Sishtla, Kamakshi
    Lambert-Cheatham, Nathan
    Lee, Bit
    Han, Duk Hee
    Park, Jaehui
    Pasha, Sheik Pran Babu Sardar
    Lee, Sanha
    Kwon, Sangil
    Muniyandi, Anbukkarasi
    Park, Bomina
    Odell, Noa
    Waller, Sydney
    Park, Il Yeong
    Lee, Soo Jae
    Seo, Seung-Yong
    Corson, Timothy W.
    CELL CHEMICAL BIOLOGY, 2022, 29 (06) : 1010 - +
  • [50] Progress with covalent small-molecule kinase inhibitors
    Zhao, Zheng
    Bourne, Philip E.
    DRUG DISCOVERY TODAY, 2018, 23 (03) : 727 - 735
12345