The Allylic Alkylation of Ketone Enolates

被引：17

作者：

Junk, Lukas ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Saarland Univ, Organ Chem 1, Campus C4-2, D-66123 Saarbrucken, Germany

来源：

CHEMISTRYOPEN | 2020年 / 9卷 / 09期

关键词：

allylic alkylations; enolates; ketones; palladium; transition metals; CATALYZED DECARBOXYLATIVE ALLYLATION; ENANTIOSELECTIVE TOTAL-SYNTHESIS; TRANSITION-METAL CATALYSIS; FORMAL SYNTHESIS; ASYMMETRIC ALKYLATION; CONJUGATE ADDITION; VINYLOGOUS ESTERS; ALPHA-ALLYLATION; INNER-SPHERE; PALLADIUM;

D O I：

10.1002/open.202000175

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The palladium-catalyzed allylic alkylation of non-stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and beta-ketoesters. The field has experienced a rapid development during the last two decades, with a range of new, highly efficient protocols evolved. In this review, the early developments as well as current methods and applications of palladium-catalyzed ketone enolate allylations will be discussed.

引用

页码：929 / 952

页数：24

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