High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome

被引：50
|
作者：
Lim, Susie [4 ]
Prasad, Mona R. [1 ]
Samuels, Philip [1 ]
Gardner, Debra K. [2 ]
Cordero, Leandro [3 ]
机构：
[1] Ohio State Univ, Med Ctr, Dept Obstet & Gynecol, Columbus, OH 43210 USA
[2] Ohio State Univ, Med Ctr, Dept Pharm, Columbus, OH 43210 USA
[3] Ohio State Univ, Med Ctr, Dept Pediat, Columbus, OH 43210 USA
[4] Kaiser Permanente NW, Dept Obstet & Gynecol, Beaverton, OR 97005 USA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 200卷 / 01期
关键词：
breastfeeding; methadone; neonatal abstinence syndrome; neonatal withdrawal; MAINTENANCE; SEVERITY; MILK;
D O I：
10.1016/j.ajog.2008.08.041
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: The purpose of this study was to examine high-dose methadone in pregnant women and its effect on the duration of neonatal abstinence syndrome. STUDY DESIGN: This was a retrospective chart review of 68 neonates and their mothers who received methadone therapy during pregnancy. The last dosage of maternal methadone just before delivery and the length of treatment for neonatal abstinence syndrome were examined with an analysis of variance model. RESULTS: When the data were analyzed for methadone dosages as a continuous variable, each 1-mg increase in the last maternal methadone dosage before delivery was associated with an additional 0.18 days of infant treatment for neonatal abstinence syndrome (P < .001; 95% CI, 0.112-0.255). In other words, every increase of 5.5 mg of methadone in the mother was associated statistically with 1 additional day of neonatal abstinence syndrome treatment for the infant. Gestational age at delivery and birthweight were not statistically significant. CONCLUSION: Higher doses of maternal methadone were associated with an increase in diagnosis and longer duration of neonatal abstinence syndrome.
引用
收藏
页码：70.e1 / 70.e5
页数：5
相关论文
共 50 条
  • [31] Ultrarapid high-dose methadone detoxification
    Prieto, IJ
    Poyo-Guerrero, R
    Fernández, R
    Ochoa, E
    PSYCHOPHARMACOLOGY, 2003, 165 (04) : 430 - 430
  • [32] Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women
    Harvey, Linda J.
    Dainty, Jack R.
    Hollands, Wendy J.
    Bull, Victoria J.
    Hoogewerff, Jurian A.
    Foxall, Robert J.
    McAnena, Liadhan
    Strain, J. J.
    Fairweather-Tait, Susan J.
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (01): : 131 - 136
  • [33] Nicotine exposure impacts severity of neonatal abstinence syndrome of neonates born to methadone-stabilized women
    Jones, H
    Tuten, M
    Fitzsimons, H
    Evans, C
    Cieslak, R
    NICOTINE & TOBACCO RESEARCH, 2005, 7 (04) : 702 - 702
  • [34] An Outpatient Methadone Weaning Program by a Neonatal Intensive Care Unit for Neonatal Abstinence Syndrome
    Lai, Andrew
    Philpot, Patrick
    Boucher, Jenny
    Meyer, Andrew
    POPULATION HEALTH MANAGEMENT, 2017, 20 (05) : 397 - 401
  • [35] Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome
    Gray, Teresa R.
    Choo, Robin E.
    Concheiro, Marta
    Williams, Erica
    Elko, Andrea
    Jansson, Lauren M.
    Jones, Hendree E.
    Huestis, Marilyn A.
    ADDICTION, 2010, 105 (12) : 2151 - 2159
  • [36] A Cohort Comparison of Buprenorphine versus Methadone Treatment for Neonatal Abstinence Syndrome
    Hall, Eric S.
    Isemann, Barbara T.
    Wexelblatt, Scott L.
    Meinzen-Derr, Jareen
    Wiles, Jason R.
    Harvey, Sharon
    Akinbi, Henry T.
    JOURNAL OF PEDIATRICS, 2016, 170 : 39 - +
  • [37] Higher maternal doses of methadone does not increase neonatal abstinence syndrome
    Pizarro, David
    Habli, Mounira
    Grier, Marquia
    Bombrys, Annette
    Sibai, Baha
    Livingston, Jeffrey
    JOURNAL OF SUBSTANCE ABUSE TREATMENT, 2011, 40 (03) : 295 - 298
  • [38] Neonatal Abstinence Syndrome in Infants with Prenatal Exposure to Methadone versus Buprenorphine
    Kushnir, Alla
    Bhavsar, Ravi
    Hanna, Emad
    Hegyi, Thomas
    CHILDREN-BASEL, 2023, 10 (06):
  • [39] Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study
    Wiles, Jason R.
    Isemann, Barbara
    Mizuno, Tomoyuki
    Tabangin, Meredith E.
    Ward, Laura P.
    Akinbi, Henry
    Vinks, Alexander A.
    JOURNAL OF PEDIATRICS, 2015, 167 (06): : 1214 - +
  • [40] Intrauterine Exposure to Methadone or Buprenorphine: Incidence and Severity of Neonatal Abstinence Syndrome
    Parige, Raghavendra
    AMERICAN JOURNAL ON ADDICTIONS, 2018, 27 (04): : 298 - 299
12345