Hypoxia-inducible factor-1 as a therapeutic target in cancer

被引：102
|
作者：
Tang, Ceen-Ming [1 ,2 ,3 ]
Yu, Jun [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 28卷 / 03期
关键词：
angiogenesis; cyclooxygenase; drug reprofiling; hypoxia-inducible factor-1; intratumoral hypoxia; prostaglandins; sphingolipids; ENDOTHELIAL GROWTH-FACTOR; HIF-1 TRANSCRIPTIONAL ACTIVITY; PROSTAGLANDIN E-2; FACTOR; 1-ALPHA; TUMOR; FACTOR-1-ALPHA; EXPRESSION; ANGIOGENESIS; HIF-1-ALPHA; PROTEIN;
D O I：
10.1111/jgh.12038
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that immortalizes tumors by inducing key genes in cancer biology, including angiogenesis, glycolysis, invasion, and metastasis. Overexpression of HIF-1 alpha is thus associated with resistance to cancer chemotherapy and increased patient mortality in several cancer phenotypes. In the present review, we summarize the role of intratumoral hypoxia and bioactive lipids in enhancing HIF-1 activity, critically discussing the potential for HIF-1 alpha inhibitors in cancer chemotherapy. Considering preclinical studies, HIF-1 inhibitors appear to have antitumor effects and thus represent a novel therapeutic strategy.
引用
收藏
页码：401 / 405
页数：5
相关论文
共 50 条
  • [41] Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1α induction in response to hypoxic stress and growth factors
    Chau, NM
    Rogers, P
    Aherne, W
    Carroll, V
    Collins, I
    McDonald, E
    Workman, P
    Ashcroft, M
    CANCER RESEARCH, 2005, 65 (11) : 4918 - 4928
  • [42] Hypoxia-inducible factor-1 (HIF-1)
    Schumacker, PT
    CRITICAL CARE MEDICINE, 2005, 33 (12) : S423 - S425
  • [43] Hypoxia-inducible factor-1 (HIF-1)
    Ke, Qingdong
    Costa, Max
    MOLECULAR PHARMACOLOGY, 2006, 70 (05) : 1469 - 1480
  • [44] Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma
    Borsi, Enrica
    Perrone, Giulia
    Terragna, Carolina
    Martello, Marina
    Dico, Angela F.
    Solaini, Giancarlo
    Baracca, Alessandra
    Sgarbi, Gianluca
    Pasquinelli, Gianandrea
    Valente, Sabrina
    Zamagni, Elena
    Tacchetti, Paola
    Martinelli, Giovanni
    Cavo, Michele
    ONCOTARGET, 2014, 5 (07) : 1779 - 1792
  • [45] Hypoxia-inducible factor-1α: A critical target for inhibiting the metastasis of hepatocellular carcinoma
    Chen, Huan
    Chen, Jing
    Yuan, Huixin
    Li, Xiuhui
    Li, Weihua
    ONCOLOGY LETTERS, 2022, 24 (02)
  • [46] Hypoxia inducible factor-1α as a potential therapeutic target for osteosarcoma metastasis
    Zhou, Jianghu
    Lan, Fengjun
    Liu, Miao
    Wang, Fengyan
    Ning, Xu
    Yang, Hua
    Sun, Hong
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [47] Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury
    Liu, Yang
    Xiang, Du
    Zhang, Hengcheng
    Yao, Hanlin
    Wang, Yanfeng
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [48] BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α
    Chen, Ni
    Chen, Xueqin
    Huang, Rui
    Zeng, Hao
    Gong, Jing
    Meng, Wentong
    Lu, Yiping
    Zhao, Fang
    Wang, Lin
    Zhou, Qiao
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (15) : 10004 - 10012
  • [49] Hypoxia-Inducible Factor-1 as Regulator of Angiogenesis in Rheumatoid Arthritis - Therapeutic Implications
    Westra, J.
    Molema, G.
    Kallenberg, C. G. M.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (03) : 254 - 263
  • [50] The Role of Hypoxia-Inducible Factor-1α in Response to Injury and Hypoxia
    Baldea, Anthony J.
    Luchette, Fred A.
    CRITICAL CARE MEDICINE, 2014, 42 (10) : 2312 - 2313
12345