Baicalin Suppresses Migration, Invasion and Metastasis of Breast Cancer via p38MAPK Signaling Pathway

被引:56
|
作者
Wang, Xiu-Feng [1 ]
Zhou, Qian-Mei [1 ]
Du, Jia [1 ]
Zhang, Hui [1 ]
Lu, Yi-Yu [1 ]
Su, Shi-Bing [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Res Ctr Tradit Chinese Med Complex Syst, Shanghai 201203, Peoples R China
关键词
Baicalin; breast cancer; MDA-MB-231; cell; metastasis; side effects; SCUTELLARIA-BAICALENSIS; MOLECULAR-MECHANISMS; UP-REGULATION; APOPTOSIS; MMP-2; EXPRESSION; MT1-MMP; KINASE; GROWTH; BAX;
D O I
10.2174/18715206113139990143
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metastasis is the major cause of death in breast cancer patients. In this study, we investigated the effects of baicalin, a natural compound, on cell migration, invasion and metastasis using human breast cancer MDA-MB-231 cell line as model system. Baicalin not only dose-dependently inhibited MDA-MB-231 cells migration and in vitro invasion, but also suppressed the tumor outgrowth and the pulmonary metastasis of MDA-MB-231 cells in xenograft model. Importantly, treatment of baicalin caused little change in body weight, liver and kidney function of recipient animals. Tumorigenesis-inhibitory effect is likely linked to the capability of baicalin to downregulate metalloproteinase (MMP)-2, MMP-9, urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) expression in MDA-MB-231 cells. As baicalin blocked p38 mitogen-activated protein kinase (MAPK) activity and treatment of p38MAPK inhibitor SB203580 led to the reduction of MMP-2, MMP-9, uPA and uPAR expressions, we concluded that baicalin suppresses the tumorigenecity of MDA-MB-231 cells by down-regulating MMP-2, MMP-9, uPA and uPAR expressions through the interruption of p38MAPK signaling pathway.
引用
收藏
页码:923 / 931
页数:9
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