Genotoxicity Assessment of Advanced Composite Material-Silicone Gel-Filled Breast Implant after Radiation Sterilization

被引：0
|
作者：
Liu, Wen [1 ,2 ]
Yang, Yang [3 ]
Liu, Qingfang [1 ]
机构：
[1] Soochow Univ, Coll Med, Sch Publ Hlth, Suzhou, Peoples R China
[2] Disease Control & Prevent Ctr Changning Area, Shanghai, Peoples R China
[3] Soochow Univ, Sch Radiat Med & protect, Suzhou, Peoples R China
来源：
ADVANCED COMPOSITE MATERIALS AND MANUFACTURING ENGINEERING | 2012年 / 583卷
关键词：
silicone gel-filled breast implant; irradiation sterilization; Ames test; micronucleus test; chromosome aberration test;
D O I：
10.4028/www.scientific.net/AMR.583.95
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The purpose of this study was to evaluate the genotoxicity of advanced composed material silicone gel-filled breast implant after irradiation sterilization, which will provide basis for the safety of such medical material in clinical application. The irradiation dose for sterilization was set according to ISO11137-2 standard. Ames test, micronucleus test and chromosome aberration test were performed to detect the genotoxicity of silicone gel-filled breast implant. No genotoxicity, no mutagenicity and no significant increase in micronucleus rate in polychromatic erythrocytes of bone marrow were observed in the samples of silicone gel-filled breast implant after irradiation sterilization. Therefore, irradiation sterilization is recommendable to be widely applied to biomedical polymer materials.
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页码：95 / +
页数：2
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