The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.
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Univ Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, England
Nsengimana, J
Bishop, T
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Univ Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, England
Bishop, T
Barrett, JH
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Univ Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Genet Epidemiol Div, Canc Res UK Clin Ctr, Leeds LS2 9JT, W Yorkshire, England