Warfare and defense: The host response to Cryptococcus infection

被引：4
|
作者：
Dutra, Fabianno F. [1 ]
Albuquerque, Priscila C. [2 ]
Rodrigues, Marcio L. [2 ,3 ]
Fonseca, Fernanda L. [2 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Lab Inflamacao & Imunidade, Dept Imunol, Rio de Janeiro, Brazil
[2] Fundacao Oswaldo Cruz Fiocruz, CDTS, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Dept Microbiol Geral, Inst Microbiol, Rio de Janeiro, Brazil
来源：
FUNGAL BIOLOGY REVIEWS | 2018年 / 32卷 / 02期
关键词：
Cryptococcus gattii; Cryptococcal infection; Cryptococcus neoformans; Host immunity; Immune response; Macrophage; COLONY-STIMULATING FACTOR; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; DENDRITIC CELL MATURATION; ALTERNATIVELY ACTIVATED MACROPHAGES; IMMUNE RECONSTITUTION SYNDROME; REGULATORY T-CELLS; PULMONARY INFECTION; NEOFORMANS INFECTION; NK CELLS;
D O I：
10.1016/j.fbr.2017.09.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal meningoencephalitis is the most fatal mycosis in AIDS patients, resulting almost 200 000 deaths annually. High cost, side effects and drug resistance are constant elements during treatment of cryptococcosis, encouraging the development of novel therapeutic strategies including immunomodulatory protocols. Thereby, to understand how the host responds to Cryptococcus is essential. In this review, we discuss the immune response against Cryptococcus and immunoevasion strategies. (C) 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：35 / 51
页数：17
相关论文
共 50 条
  • [21] Fibrin and fibrinolysis in infection and host defense
    Degen, J. L.
    Bugge, T. H.
    Goguen, J. D.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 : 24 - 31
  • [22] ANOREXIA OF INFECTION AS A MECHANISM OF HOST DEFENSE
    MURRAY, MJ
    MURRAY, AB
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1979, 32 (03): : 593 - 596
  • [23] VIRAL-INFECTION AND HOST DEFENSE
    CARTER, WA
    DECLERCQ, E
    SCIENCE, 1974, 186 (4170) : 1172 - 1178
  • [24] ANOREXIA OF INFECTION AS A MECHANISM OF HOST DEFENSE
    KAMINSKI, MV
    ARMSTRONG, MK
    CHERNY, E
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 1979, 32 (11): : 2167 - 2167
  • [25] CYCLOSPORINE-A AND HOST DEFENSE IN INFECTION
    ORMROD, DJ
    CAWLEY, S
    MILLER, TE
    KIDNEY INTERNATIONAL, 1990, 38 (03) : 556 - 556
  • [26] HOST DEFENSE MECHANISMS AGAINST INFECTION
    ALEXANDER, JW
    SURGICAL CLINICS OF NORTH AMERICA, 1972, 52 (06) : 1367 - +
  • [27] Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii
    Holcomb, Zachary E.
    Steinbrink, Julie M.
    Zaas, Aimee K.
    Betancourt, Marisol
    Tenor, Jennifer L.
    Toffaletti, Dena L.
    Alspaugh, J. Andrew
    Perfect, John R.
    McClain, Micah T.
    JOURNAL OF FUNGI, 2022, 8 (05)
  • [28] Production of IL-17A at Innate Immune Phase Leads to Decreased Th1 Immune Response and Attenuated Host Defense against Infection with Cryptococcus deneoformans
    Sato, Ko
    Yamamoto, Hideki
    Nomura, Toshiki
    Kasamatsu, Jun
    Miyasaka, Tomomitsu
    Tanno, Daiki
    Matsumoto, Ikumi
    Kagesawa, Takafumi
    Miyahara, Anna
    Zong, Tong
    Oniyama, Akiho
    Kawamura, Kotone
    Yokoyama, Rin
    Kitai, Yuki
    Ishizuka, Shigenari
    Kanno, Emi
    Tanno, Hiromasa
    Suda, Hiromi
    Morita, Masanobu
    Yamamoto, Masayuki
    Iwakura, Yoichiro
    Ishii, Keiko
    Kawakami, Kazuyoshi
    JOURNAL OF IMMUNOLOGY, 2020, 205 (03): : 686 - 698
  • [29] Extracellular proteins of Cryptococcus neoformans and host antibody response
    Chen, LC
    Pirofski, LA
    Casadevall, A
    INFECTION AND IMMUNITY, 1997, 65 (07) : 2599 - 2605
  • [30] T-HELPER CELLS AND HOST DEFENSE TO CRYPTOCOCCUS-NEOFORMANS IN THE LUNG
    MOODY, CH
    LIPSCOMB, MF
    TOEWS, GB
    CHEST, 1989, 95 (03) : S172 - S172
12345