MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

被引：114

作者：

Noh, Ji Heon ^{[1
,2
]}

Chang, Young Gyoon ^{[1
,2
]}

Kim, Min Gyu ^{[1
,2
]}

Jung, Kwang Hwa ^{[1
,2
]}

Kim, Jeong Kyu ^{[1
,2
]}

Bae, Hyun Jin ^{[1
,2
]}

Eun, Jung Woo ^{[1
,2
]}

Shen, Qingyu ^{[1
,2
]}

Kim, Seung-Jin ^{[1
,2
]}

Kwon, So Hee ^{[3
]}

Park, Won Sang ^{[1
]}

Lee, Jung Young ^{[1
,2
]}

Nam, Suk Woo ^{[1
,2
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pathol, Lab Oncogenom, Seoul 137701, South Korea

[2] Catholic Univ Korea, Funct RNom Res Ctr, Seoul 137701, South Korea

[3] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Inchon 406840, South Korea

来源：

CANCER LETTERS | 2013年 / 335卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

MiR-145; HDAC2; Tumor suppressor; Liver cancer; INCREASED EXPRESSION; MICRORNAS; GENE; STRATEGIES; INDUCTION; GROWTH; HDACS;

D O I：

10.1016/j.canlet.2013.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：455 / 462

页数：8

共 50 条

[31] miR-148b-3p functions as a tumor suppressor in GISTs by directly targeting KIT
Wang, Yu
Li, Jun
Kuang, Dong
Wang, Xiaoyan
Zhu, Yuanli
Xu, Sanpeng
Chen, Yaobing
Cheng, Henghui
Zhao, Qiu
Duan, Yaqi
Wang, Guoping
CELL COMMUNICATION AND SIGNALING, 2018, 16
[32] MiR-610 functions as a tumor suppressor in oral squamous cell carcinoma by directly targeting AGK
Yao, L-X
Liu, J.
Xu, L.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (01) : 187 - 197
[33] miR-103 Functions as a Tumor Suppressor by Directly Targeting Programmed Cell Death 10 in NSCLC
Yang, Dong
Wang, Jian-Jun
Li, Jin-Song
Xu, Qian-Yu
ONCOLOGY RESEARCH, 2018, 26 (04) : 519 - 528
[34] miR-145 inhibits tumor proliferation and invasion and induces apoptosis in gastric cancer by targeting c-Myc
Zou, Fangwen
Tang, Yifang
Zhang, Leiyi
Zhou, Yueying
Yang, Zhigang
Du, Zheng
Sheng, Zengmei
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (05): : 4928 - 4934
[35] Circ_0017247 induces Wilms' tumor metastasis through targeting miR-145
Du, Aihua
MINERVA MEDICA, 2021, 112 (06) : 826 - 828
[36] miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer
Kong, Qinglong
Shu, Nan
Li, Jun
Xu, Ning
ONCOLOGY RESEARCH, 2018, 26 (05) : 735 - 741
[37] miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer (vol 12, 945057, 2022)
Choi, Sujin
Lee, Soonchul
Han, Young-Hoon
Choi, Junwon
Kim, Isaac
Lee, Jusung
An, Hyun-Ju
FRONTIERS IN ONCOLOGY, 2024, 14
[38] MIR-15A FUNCTIONS AS A TUMOR SUPPRESSOR FOR PROSTATE CANCER BY TARGETING MULTIPLE ONCOGENES
Kojima, S.
Watanabe, R.
Tsukada, J.
Furuya, Y.
Seki, N.
EUROPEAN UROLOGY SUPPLEMENTS, 2009, 8 (04) : 315 - 315
[39] MIR-15A FUNCTIONS AS A TUMOR SUPPRESSOR FOR PROSTATE CANCER BY TARGETING MULTIPLE ONCOGENES
Satoko, Kojima
Watanabe, Ryoko
Tsukada, Jun
Furuya, Yuzo
Seki, Naohiko
JOURNAL OF UROLOGY, 2009, 181 (04): : 396 - 397
[40] MiR-873 functions as a potential tumor suppressor in pancreatic cancer by targeting KRAS
Mokhlis, Hamada A.
Bayraktar, Recep
Kabil, Nashwa N.
Kahraman, Nermin
Bouchard, Richard
Abdelghany, Tamer
Ashour, Ahmed
Abdel-Aziz, Abdel-Aziz H.
Calin, George A.
Lopez-Berestein, Gabriel
Ozpolat, Bulent
CANCER RESEARCH, 2018, 78 (13)

← 1 2 3 4 5 →