A clinical and epidemiological review of non-toxigenic Clostridium difficile

被引：51
|
作者：
Natarajan, Mukil [1 ]
Walk, Seth T. [1 ,2 ]
Young, Vincent B. [1 ,3 ]
Aronoff, David M. [1 ,3 ]
机构：
[1] Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
[2] Montana State Univ, Dept Microbiol, Bozeman, MT 59717 USA
[3] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
来源：
ANAEROBE | 2013年 / 22卷
基金：
美国国家卫生研究院;
关键词：
Clostridium difficile; Non-toxigenic Clostridium difficile; Probiotic; Hamsters; Humans; CLINDAMYCIN-ASSOCIATED COLITIS; FIELD GEL-ELECTROPHORESIS; INTENSIVE-CARE-UNIT; TOXIN-B; PSEUDOMEMBRANOUS COLITIS; PATHOGENIC STRAINS; COLONIZATION; PREVALENCE; HAMSTERS; DIARRHEA;
D O I：
10.1016/j.anaerobe.2013.05.005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridium difficile is a significant nosocomial threat to human health and is the most commonly identified cause of antibiotic-associated diarrhea. The development of C difficile colitis requires production of toxins A and/or B, but some strains do not express these proteins. These non-toxigenic C difficile (NTCD) have garnered attention for their capacity to colonize humans and potentially reduce the risk for symptomatic colitis caused by toxigenic strains. Isolates of NTCD have been obtained from the environment as well as from animal and human sources. Studies in a hamster CDI model have demonstrated a protective effect of NTCD against toxigenic infection. The extent to which this protective effect of NTCD occurs in humans remains to be defined. Evidence for a therapeutic or preventive role for NTCD is limited but clinical prophylaxis studies are ongoing. NTCD potentially represents an exciting new tool in preventing CDI and its recurrences. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1 / 5
页数：5
相关论文
共 50 条
  • [31] CLOSTRIDIUM-DIFFICILE - A TOXIGENIC PATHOGEN
    BURDON, DW
    MEDICAL LABORATORY SCIENCES, 1981, 38 (03): : 253 - 258
  • [32] Toxigenic Clostridium difficile colonization in children
    Armin, Shahnaz
    Babaie, Delara
    Karimi, Abdollah
    Fallah, Fatemeh
    JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, 2009, 4 (04) : 375 - 378
  • [33] Phenotypic Characterization of Non-toxigenic Clostridioides difficile Strains Isolated From Patients in Mexico
    Camorlinga, Margarita
    Sanchez-Rojas, Michelle
    Torres, Javier
    Romo-Castillo, Mariana
    FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [34] Antibiogram patterns of non-toxigenic, CDT-producing C. difficile ribotypes
    Androga, Grace O.
    Lim, Su Chen
    Knight, Daniel R.
    Chang, Barbara J.
    Foster, Niki F.
    Riley, Thomas V.
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2017, 50 : S77 - S77
  • [35] Multicenter Clinical Evaluation of the Portrait Toxigenic C. difficile Assay for Detection of Toxigenic Clostridium difficile Strains in Clinical Stool Specimens
    Buchan, Blake W.
    Mackey, Tami-Lea A.
    Daly, Judy A.
    Alger, Garrison
    Denys, Gerald A.
    Peterson, Lance R.
    Kehl, Sue C.
    Ledeboer, Nathan A.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (12) : 3932 - 3936
  • [36] The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain
    Zhang, Keshan
    Zhao, Song
    Wang, Yuankai
    Zhu, Xuejun
    Shen, Hong
    Chen, Yugen
    Sun, Xingmin
    ANAEROBE, 2015, 36 : 49 - 52
  • [37] Comparison of toxigenic and non toxigenic Clostridium difficile on T84 cell inflammatory phenotype
    Canny, GO
    Drudy, D
    Mac Mathuna, P
    O'Farrelly, C
    Baird, AW
    GASTROENTEROLOGY, 2001, 120 (05) : A326 - A326
  • [38] (Non)toxigenic Clostridium difficile colonization and the risk of atopic manifestations in infancy
    Penders, J.
    Stobberingh, E. E.
    van den Brandt, P. A.
    van Ree, R.
    Thijs, C.
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2009, 21 (03) : A44 - A44
  • [39] Clinical significance of direct cytotoxicity and toxigenic culture in Clostridium difficile infection
    Reigadas, E.
    Alcala, L.
    Marin, M.
    Munoz-Pacheco, P.
    Catalan, P.
    Martin, A.
    Bouza, E.
    ANAEROBE, 2016, 37 : 38 - 42
  • [40] Clostridium difficile infection: clinical, epidemiological and therapeutic aspects
    Barbut, F.
    Le Monnier, A.
    Eckert, C.
    REANIMATION, 2012, 21 (02): : S373 - S383
12345